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This study shows that KV2.1 macro-clusters regulate sex-specific differences in CaV1.2 clustering and function in arterial myocytes by modulating phosphorylation at S590.

This study shows that B cell pyruvate oxidation supports antigen-specific activation, driving inflammation and fibrosis in MASH.

This study investigates cardiac dysfunction in Friedreich's Ataxia by analyzing calcium handling proteins and mitochondrial function in both mouse models and human samples, finding reduced expression of key proteins and mitochondrial abnormalities.

This study compares the reaction norms of two oyster species to ocean acidification, finding that intertidal oysters show better acclimation potential than subtidal ones.

The paper identifies the Aster pathway as critical for dietary cholesterol uptake and shows it can be targeted with a small molecule inhibitor.

This study shows that AMPK is necessary for exercise-induced liver adaptations in glycogen and lipid metabolism in mice.

This paper develops a modified Langendorff setup to simultaneously record electrical and mechanical function in isolated mouse hearts, revealing electro-mechanical interactions during bigeminy and ischemia-reperfusion.

This paper introduces a non-invasive method to measure C. elegans ageing by monitoring movement, showing it can detect ageing interventions more efficiently than traditional lifespan assays.

This study shows that EG00229, designed to inhibit VEGF-NRP1 interaction, paradoxically increases vascular leakage by activating NRP1-dependent signaling pathways.

This paper uses Bayesian methods to analyze heart rate dynamics during psychedelic experiences, finding increased entropy and variability linked to subjective and neural effects.

This study shows vascular endothelial cells sense laminar and disturbed flows through changes in plasma and mitochondrial membrane lipid order, leading to distinct mitochondrial responses.

This study shows auxin exposure affects adult Drosophila feeding behavior and fatty acid metabolism but not fecundity or progeny survival.

This study shows that low-dose angiotensin II induces early inflammatory responses in cardiac arteries of normotensive mice, primarily via AT1 receptors, with AT2 receptors modulating IL-1β production.

This study identifies PIEZO2 as a mechanotransducer in juxtaglomerular cells that regulates renin release and blood pressure.

This study investigates the physiological effects of acute dehydration in cactus mice, finding reduced energy expenditure, weight loss, and sex-specific changes in body temperature.

This study shows that deleting the AHR in endothelial cells improves ischemic angiogenesis in male CKD mice but not females, revealing sex-dependent differences in AHR activation and angiogenic signaling.

The paper validates the use of a Clark electrode as a respirometer for measuring oxygen consumption in ants, revealing discontinuous respiration patterns in queens and workers.

This study uses Drosophila tissue-specific gene knockdown to assess the functional impact of seven conserved disease genes, showing their effects on viability, behavior, and neuronal survival.

This study shows that deleting the VPAC2R gene in female mice increases basal glycemia and impairs insulin response during metabolic stress, while also enhancing hyperglycemia during psychogenic stress.

This study identifies metabolites and pathways associated with thrombosis after cardiac surgery in children with congenital heart disease using untargeted metabolomics.