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Psychoneuroimmunology of Viral Hepatitis and Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

This study conducts a systematic review and meta-analysis of 24 studies to explore the link between viral hepatitis, hepatocellular carcinoma, and neuropsychiatric disorders, identifying immune and inflammatory mechanisms.

Slowed aquatic invasion coincides with intensified research and prevention in Minnesota, USA

The paper measures the effectiveness of aquatic invasive species prevention in Minnesota by showing slowed invasion rates alongside increased prevention efforts and simulations suggesting a 20-53% reduction in new invasions.

PP271, a novel bacteriophage primase-polymerase, enables Primer-Free DNA Amplification

This paper characterizes PP271, a novel bacteriophage PrimPol enzyme, showing it can synthesize DNA primers that are efficiently extended by Phi29 DNA polymerase for primer-free amplification.

Early visual cortex is not functionally necessary for temporal attention: A TMS study

PCB-Exposed Gut Microbiota Recapitulate Neurobehavioral Deficits and Reprogram Hippocampal Transcriptomic Signatures

This study shows that transferring PCB-exposed gut microbiota to offspring reproduces neurobehavioral deficits and induces sex-biased molecular changes in the brain.

Cholinergic modulation engages a CHRM1-IL-17 neuroimmune axis to promote diabetic wound repair

The paper identifies a CHRM1-IL-17 neuroimmune axis that promotes diabetic wound healing through cholinergic modulation and local AChE inhibition.

Neonatal personality is associated with sex-specific developmental trajectories in a wild mammal

The paper examines neonatal personality traits in wild fallow deer and finds sex-specific links between early behavioral reactivity and later developmental outcomes.

Trunk muscle activity across various trunk-limb coordination patterns in centipede locomotion

This study examines trunk muscle activity in centipedes during different locomotion patterns, finding that the same muscles serve contrasting roles in generating undulation or straightening the trunk.

BioMeme: biological response memory for virtual cells

BioMeme predicts cell responses to new perturbations by recalling measured experiments, outperforming neural models in accuracy and speed.

Positive cooperativity enhances coupling of a second G protein to a GPCR dimer

The paper shows that a second G protein couples with higher affinity to a GPCR dimer than the first, due to conformational stabilization by the first G protein.

Ok-k-mer: Selecting k-mer length ensembles for calculating genomic distance

Ok-k-mer selects optimal k-mer length ensembles to improve genomic distance estimation by maximizing correlation with phylogenetic branch distances.

Mucin promotes pneumococcal colonization via autolysis suppression and tryptophan-mediated immune modulation

This study shows that mucin promotes pneumococcal colonization by suppressing autolysis and modulating immune responses through tryptophan biosynthesis.

A Human Tumor Virus Recruits HSP70 Chaperone to Remodel Its Replisome on DNA

This study shows that MCV small T protein recruits HSP70 to facilitate LT helicase remodeling and DNA unwinding, revealing a conserved mechanism for replication complex assembly.

S. pombe Mto1:Mto2 stabilizes γ-tubulin positions within the γ-TuRC

This study shows that Mto1 and Mto2 stabilize γ-tubulin positions in fission yeast γ-TuRCs, enabling microtubule nucleation through structural modulation.

Robust planar morphogenesis in leaf-like organs requires callose-dependent coordination of division and growth

This study shows that callose-dependent coordination between cell division and growth is essential for planar morphogenesis in moss phyllids.

Modular assembly of mitochondrial complex III from a dynamic matrix domain pool

This study reveals how mitochondrial complex III assembles from preformed matrix domain modules, showing dynamic subunit exchange and the role of specific residues in assembly and disease.

Integrated genotyping, annotation and epigenetic characterization of transposable elements with GraffiTE

GraffiTE v1.1 is a Nextflow pipeline that genotypes structural variants, annotates polymorphic mobile elements, and maps epigenetic data to transposable elements using pangenome graphs, revealing hypomethylated elements and age-related demethylation.

ApoE isoforms establish distinct antioxidant trajectories across the aging brain

This study shows ApoE isoforms influence antioxidant pathways differently across aging, with ApoE4 showing stronger transcriptional responses but less effective protein production, linking to neurodegenerative risk.

Nanomechanical phenotyping uncovers a non-canonical smooth muscle-like hypercontractility program in lung squamous cell carcinoma myofibroblasts

The paper identifies a non-canonical smooth muscle-like hypercontractility program in LUSC myCAFs using nanomechanical phenotyping, linking it to tumor mechanics and adverse outcomes.

FACT frees Ubp10 from nucleosome sequestration after rapid H2B deubiquitination

The paper shows that FACT facilitates Ubp10 release from nucleosomes after H2B deubiquitination, revealing release as the rate-limiting step for Ubp10 turnover.