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Ultradeep optical coherence tomography

This paper introduces ultradeep OCT to image deep brain structures with improved depth and resolution, demonstrating its potential for studying neurodegenerative diseases.

The ecological niche and seasonality of Theileria equi in Portugal

This study identifies spatio-temporal dynamics and ecological niche factors influencing Theileria equi infection in Portugal using field-surveillance data and environmental variables.

HOT1 functions as a homodimer to promote ALT-permissive chromatin

This study shows HOT1 functions as a homodimer to maintain an ALT-permissive chromatin state at telomeres.

Functional ultrasound imaging in free-moving marmosets reveals that intra-call prosodic features modulate large-scale cortical dynamics

This study uses functional ultrasound imaging in marmosets to show that intra-call prosodic features influence large-scale cortical dynamics during vocal interactions.

NRT2.2 is essential for nitrate uptake and carbon-nitrogen balance in Nannochloropsis oceanica

This study identifies NRT2.2 as the primary nitrate transporter in Nannochloropsis oceanica and shows its critical role in nitrate uptake and carbon-nitrogen balance.

A comparison of two culture and three sequencing methods for detection of the urobiome

This study compares five methods for detecting the urobiome in urine samples, finding that shotgun metagenomic sequencing provides the broadest species-level view, while culture methods have specific strengths.

Msp300 Links Autophagy to Nuclear Morphodynamics

This study identifies Msp300 as a novel interactor of Atg8a in Drosophila, linking autophagy to nuclear architecture through the LINC complex.

Dyskinesia induced by a dopamine 2 receptor-like agonist, but not a dopamine 1 receptor-like agonist, is blocked by sub-anesthetic ketamine

This study shows that sub-anesthetic ketamine reduces dyskinesia caused by D2R-like receptor agonists but not D1R-like receptor agonists in L-DOPA-primed rats.

Serial intravascular labeling resolves dynamic decidual NK residency and gestational remodeling toward T-bet-Low states

This study uses serial intravascular labeling to show dynamic changes in decidual NK cell residency and T-bet expression during pregnancy.

DPYD links glial lipids and myelination to sleep duration

This study identifies DPYD's role in sleep regulation through glial lipid metabolism and myelination across species, linking genetic variants to oligodendrocyte-specific control.

Serotonin signals through ciliary 5-HT6 to control insulin secretion

This study shows that the 5-HT6 receptor in pancreatic beta cells, localized to cilia, enhances insulin secretion, highlighting ciliary localization as a key determinant of GPCR function.

Locus Coeruleus activity correlates with transient elevations in breathing during opioid-induced respiratory depression

This study shows that fentanyl increases locus coeruleus bursts and transient breathing elevations, with divergent respiratory responses after repeated opioid use.

PERTURBATION OF THE AMINO ACID STRESS RESPONSE PATHWAY EXPOSES A METABOLIC VULNERABILITY IN MULTIPLE AGGRESSIVE CANCER SUBTYPES

This study shows that disrupting the amino acid stress response pathway reduces tumor growth in multiple aggressive cancers by targeting chronic metabolic stress adaptation.

Predicting cortical signal mixing in coarse-resolution fMRI: a forward-operator analysis of surface mapping and the conditional benefit of correction

This paper develops a forward-operator model to predict signal mixing in fMRI and shows that correcting for it improves coarse-resolution cortical mapping.

CO2-concentrating nanoparticles drive progressive photosynthetic and cell-wall remodelling in Arabidopsis thaliana cells

The paper shows that CO2-concentrating nanoparticles modify photosynthesis and cell wall structure in Arabidopsis cells over time.

Species-specific WNT requirements shape somite morphogenesis in mammalian embryo models

This study compares somitogenesis across human, pig, sheep, and cow stem cell-derived embryo models, revealing species-specific WNT signaling and extracellular matrix requirements for axial segmentation.

Mapping the sequence determinants of constitutive activity in GPCRs

The paper measures basal activity across the human GPCR family on a single scale and identifies key residues that influence constitutive signaling.

Antibiotics drive immunometabolic rewiring of human immune responses

This study examines how antibiotics affect immune cell function by altering mitochondrial activity, showing antibiotic-specific immunomodulatory effects in humans and mice.

Gut microbiome-associated adaptability of suckermouth catfish inhabiting the polluted Buriganga River: insights into heavy-metal-remediating microorganisms

This study identifies heavy-metal-remediating bacteria in the gut microbiome of suckermouth catfish from the polluted Buriganga River, highlighting their potential for bioremediation.

Ranging and territoriality in African Apes

The paper compares ranging and territoriality among African apes, finding that economic defendability does not fully explain interspecific variation in territorial behavior.