X. Dai

Born on Mars: Multigenerational phenotypic change in Caenorhabditis elegans under Martian analog gravity and hypomagnetic fields

This study examines transgenerational effects of Martian analog gravity and hypomagnetic fields on C. elegans, finding progressive impairments and increased phenotypic variability across generations.

Basophils drive the resolution and promote wound healing in adult and aged mice

This study shows basophils promote inflammation resolution and wound healing in both adult and aged mice by driving tissue remodeling and immunoregulatory functions.

An optimized somatic embryo transformation system assisted homozygous edited rubber tree generation method mediated by CRISPR/Cas9

This study develops a CRISPR/Cas9-based method to generate homozygous edited rubber tree plants by optimizing somatic embryo transformation and subculture procedures.

Targeting CD19 for the treatment of autoimmune with a novel T cell engager

This study develops YK012, a T cell engager targeting CD19, showing potential for treating autoimmune diseases with improved efficacy and reduced side effects compared to existing therapies.

The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis

This study shows that Zbtb24 regulates B1 cell differentiation via heme synthesis, leading to impaired antibody production in T-cell independent responses.

High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer

This study introduces Telo-seq, a method using long-read sequencing to measure telomere lengths with high resolution, revealing dynamics in aging and cancer.

A muscle hypertrophy-derived myokine reprograms the stromal vascular fractions differentiation towards thermogenic adipocytes in subcutaneous adipose tissue

This study identifies Thbs4 as a muscle-derived myokine that promotes the conversion of white to beige adipocytes in subcutaneous adipose tissue, improving metabolic health and protecting against high-fat diet-induced disorders.

Distinct Microstructural Heterogeneities Underpin Specific Micromechanical Properties in Human ACL Femoral and Tibial Entheses

This study identifies distinct microstructural and biomolecular features in ACL femoral and tibial entheses that contribute to their specific mechanical properties.

Borg extrachromosomal elements of methane-oxidizing archaea have conserved and expressed genetic repertoires

The paper identifies conserved genetic repertoires in Borg extrachromosomal elements of methane-oxidizing archaea and shows their higher expression than host genes.

Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie Bandavirus in aged ferrets

This paper develops a self-assembling ferritin nanoparticle vaccine targeting DBV Gn head region that fully protects aged ferrets from lethal DBV challenge.

How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot

The paper identifies NINJ1 as an active mediator of plasma membrane rupture and explains why NINJ2 cannot, through structural and functional analysis of their filaments.

Epidermal Growth Factor potentiates EGFR(Y992/1173)-mediated therapeutic response of triple negative breast cancer cells to cold atmospheric plasma-activated medium

The paper shows EGF enhances TNBC cells' response to CAP-activated medium by activating specific EGFR phospho-tyrosines and increasing ROS levels.

Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and function

The paper identifies ADA as a metabolic regulator that enhances CAR-T cell function and tumor clearance through improved metabolism and reduced exhaustion.

Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease

This study identifies TRMT1 as a target of SARS-CoV-2 Mpro, showing cleavage disrupts its tRNA methyltransferase activity and impacts host translation and oxidative stress response.

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike

The paper identifies mutations that stabilize the prefusion conformation of SARS-CoV-2 spike while improving expression, using a combination of fluorescence-based assays, cell display, and deep mutational scanning.

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer

This study identifies Pygo2 as a driver oncogene in prostate cancer that suppresses immune infiltration and response to immunotherapy, showing that its inhibition enhances anti-tumor immunity.

Single-cell multi-omics defines the cell-type specific impact of splicing aberrations in human hematopoietic clonal outgrowths

This study introduces GoT-Splice, a multi-omics method to analyze splicing aberrations in human hematopoietic cells, revealing cell-type specific effects of SF3B1 mutations in clonal outgrowths.

Intermittent fasting mitigates cognitive deficits in Alzheimer's disease via the gut-brain axis

This study shows intermittent fasting improves cognitive function in Alzheimer's mice by reducing Aβ and neuroinflammation, and through gut microbiota and metabolite changes.

Distinct Mechanisms of Innate and Adaptive Immune Regulation Underlie Poor Oncologic Outcomes Associated with KRAS-TP53 Co-Alteration in Pancreatic Cancer

Distribution of Critical Areas for Ecological Conservation in Multiple Scenarios ---- Emphasizing the Impact of Human Activities

This study identifies critical ecological protection areas in Aksu City and Wensu County by simulating human activity impacts and analyzing resistance surfaces across different scenarios.

Genomic insights into the phylogeny and biomass-degrading enzymes of rumen ciliates

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

Bioactive constituents of Verbena officinalis alleviate inflammation and enhance killing efficiency of natural killer cells

This study shows that Verbena officinalis extract reduces inflammation and enhances NK cell killing efficiency, with Verbenalin specifically improving viral infection response.

Highly concentrated trehalose induces transient senescence-associated secretory phenotype in fibroblasts via CDKN1A/p21

High-concentration trehalose induces a beneficial senescence-associated secretory phenotype in fibroblasts via CDKN1A/p21, enhancing wound repair in mice.

Local conjugation of auxin by the GH3 amido synthetases is required for normaldevelopment of roots and flowers in Arabidopsis

This study shows that GH3 amido synthetases conjugate auxin, and their deletion causes developmental defects in Arabidopsis roots and flowers.

The Hippo pathway regulates density-dependent proliferation of iPSC-derived cardiac myocytes

This study shows that the Hippo pathway regulates density-dependent proliferation of iPSC-derived cardiac myocytes by modulating YAP/TAZ activity, with small molecules enhancing proliferation in low-density conditions.

Combined MEK and STAT3 inhibition reprograms stromal inflammation to overcome immunotherapy resistance in pancreatic cancer

This paper shows that combining MEK and STAT3 inhibitors reprograms stromal inflammation and enhances immunotherapy response in pancreatic cancer.

Intrinsic cardiac adrenergic cells contribute to septic cardiomyopathy

This study identifies intrinsic cardiac adrenergic cells as contributors to septic cardiomyopathy by releasing norepinephrine that exacerbates cardiac dysfunction through β1-adrenergic receptor activation.

Selection on ancient variations drives the adaptive radiation of Metrosideros across the Hawaiian archipelago

This study investigates how ancient genetic variations drive adaptive radiation in Hawaiian Metrosideros, showing balancing selection on pre-existing haplotypes facilitates diversification despite limited genetic diversity.

Transferrin receptor (Tfr1) ablation in satellite cells impacts skeletal muscle regeneration through the activation of ferroptosis

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

Predicting transcriptional responses to cold stress across plant species

The paper trains a classifier to predict cold stress transcriptional responses across plant species using genomic features, showing cross-species prediction accuracy.