Author

A. Acar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. Sottoriva· 2 shared G. D. Cresswell· 2 shared G. Vlachogiannis· 2 shared I. Spiteri· 2 shared L. Magnani· 2 shared N. Valeri· 2 shared A. Graudenzi· 1 shared A. Hidalgo-Sastre· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersCancer Biology

A. Sottoriva

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Epigenetic heritability of cell plasticity drives cancer drug resistance through one-to-many genotype to phenotype mapping

J. Fernandez-Mateos, S. Milite, E. Oliveira, G. Vlachogiannis, B. Chen, E. Yara, G. D. Cresswell, C. James, L. Patruno, G. Ascolani, A. Acar, T. Heide, I. Spiteri, A. Graudenzi, G. Caravagna, , A. Sottoriva

The paper shows how epigenetic heritability of cell plasticity contributes to cancer drug resistance through a one-to-many genotype-to-phenotype mapping.

bioRxiv · Nov 15, 2023 · PreprintCancer Biology

Inhibition of Wnt signalling by Notch via two distinct mechanisms

A. Acar, A. Hidalgo-Sastre, M. K. Leverentz, C. Mills, S. Woodcock, M. Baron, G. Collu, K. Brennan

The paper identifies two distinct mechanisms by which Notch inhibits Wnt signaling by limiting β-catenin transcriptional activity in vertebrate cells.

bioRxiv · Apr 14, 2020Cell Biology

Exploiting evolutionary herding to control drug resistance in cancer

A. Acar, D. Nichol, J. Fernandez, G. D. Cresswell, I. Barozzi, S. P. Hong, I. Spiteri, M. Stubbs, R. Burke, A. Stewart, G. Vlachogiannis, C. C. Maley, L. Magnani, N. Valeri, U. Banerji, A. Sottoriva

This paper demonstrates evolutionary herding in non-small cell lung cancer to control drug resistance by shifting clonal composition and inducing collateral sensitivity.

bioRxiv · Mar 4, 2019 · PreprintCancer Biology