A. B. Balazs

This study designs immunogens by grafting SARS-2 RBM onto heterologous sarbecovirus scaffolds to elicit broad neutralizing antibodies against sarbecoviruses.

This study shows that HSV-specific monoclonal antibodies transferred from mothers or directly administered to neonatal mice reduce HSV-induced mortality and morbidity.

This study shows DNA origami scaffolds enhance antibody responses to SARS-CoV-2 RBD without inducing immune memory against the scaffold itself, compared to protein-based VLPs.

The paper investigates the role of IgG subclasses in HIV prevention using humanized mice, finding that VRC07-IgG1 provides substantial protection despite low concentrations.

This study compares humoral immune responses to mRNA vaccines in children aged 6-11 years, finding that a 100g dose elicits robust and dose-dependent cross-VOC antibody responses with preserved functional immunity.

This study shows that macrophages mediate antiviral responses in human lung tissues, protecting against SARS-CoV-2 infection through the USP18-ISG15 axis.

This study shows that TBK1-primed dendritic cells reduce HIV-1 disease progression in humanized mice by enhancing CD8+ T cell responses.

This study designs immunogens that focus immune responses to the SARS-CoV-2 receptor binding motif, enhancing neutralizing antibody breadth against related sarbecoviruses.

The paper isolates naive B cells targeting SARS-CoV-2 RBD and shows they can neutralize the virus and variants.

This study shows that a cocktail of trimeric sarbecovirus receptor binding domains elicits broadly neutralizing antibodies against multiple sarbecoviruses, including in the context of prior SARS-CoV-2 immunity.

The paper profiles human fetal liver hematopoietic stem cells using multi-modal data to identify a molecular signature associated with engraftment potential.

This paper provides a protocol for pseudotyping lentiviral particles with SARS-CoV-2 Spike protein to measure neutralizing antibody activity in a luciferase-based assay.