F. Douam

Immune Signatures of SARS-CoV-2 Infection Resolution in Human Lung Tissues

This study identifies immune signatures associated with SARS-CoV-2 infection resolution in human lung tissues using a humanized mouse model.

A Drug-Free Pathogen Capture and Neutralizing Nasal Spray to Prevent Emerging Respiratory Infections

This paper introduces a drug-free nasal spray that captures and neutralizes respiratory pathogens, showing high efficacy in mice against influenza.

Complete substitution with modified nucleotides suppresses the early interferon response and increases the potency of self-amplifying RNA

This paper shows that complete substitution of nucleotides in self-amplifying RNA (saRNA) reduces interferon response and enhances expression, improving vaccine potency.

Persistent hepatitis B virus and HIV coinfections in dually humanized mice engrafted with human liver and immune system

This study shows that dually humanized mice can support persistent HBV and HIV coinfections, enabling research on immune dysregulation and immunotherapeutic testing.

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1Omicron

This study compares the pathogenicity and immune evasion of an Omicron S-bearing virus with natural Omicron, showing vaccine escape via S mutations but severe disease due to factors outside S.

Platelet proteome analysis reveals an early hyperactive phenotype in SARS-CoV-2-infected humanized ACE2 mice

This paper uses proteomics to analyze platelet changes in SARS-CoV-2-infected humanized mice, finding early activation of coagulation and complement pathways.

Macrophages govern antiviral responses in human lung tissues protected from SARS-CoV-2 infection

This study shows that macrophages mediate antiviral responses in human lung tissues, protecting against SARS-CoV-2 infection through the USP18-ISG15 axis.

Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression

This study investigates SARS-CoV-2 infection in K18-hACE2 mice, showing neuroinvasion and neuronal injury are key to lethality, with viral tropism not fully dependent on hACE2 expression.

SARS-CoV-2 Requires Cholesterol for Viral Entry and Pathological Syncytia Formation

This study identifies cholesterol's essential role in SARS-CoV-2 membrane fusion and syncytia formation, suggesting statins may benefit COVID-19 patients.

SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway

This study identifies SARS-CoV-2 inhibition of the JAK-STAT pathway as a mechanism to suppress interferon signaling across diverse cell types.

The Effect Of Famotidine On SARS-CoV-2 Proteases And Virus Replication

This study investigates famotidine's effect on SARS-CoV-2 proteases and virus replication, finding no direct inhibition of 3CLpro, PLpro, or viral replication at high concentrations.

A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating

This study identifies VCP/p97 as essential for flavivirus nucleocapsid disassembly using a YFV entry reporter system.