Author

E.-C. Wamhoff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 2 Immunology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 4 Organism:mouse· 3 Assay:proteomics· 3 Approach:deep learning· 2 Assay:DNA methylation· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

M. Bathe· 4 shared C. Rademacher· 2 shared G. A. Knappe· 2 shared H. Huang· 2 shared R. R. Du· 2 shared A. A. Burds· 1 shared A. B. Balazs· 1 shared A. Caflisch· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBioengineering

M. Bathe

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Evaluation of non-modified wireframe DNA origami for acute toxicity and biodistribution in mice

E.-C. Wamhoff, G. A. Knappe, A. A. Burds, R. R. Du, B. Neun, S. Difilippantonio, C. Sanders, E. Edmondson, J. L. Matta, M. Dobrovolskaia, M. Bathe

This study evaluates the acute toxicity and biodistribution of non-modified wireframe DNA origami nanoparticles in mice, finding no toxicity and minimal immunotoxicity.

bioRxiv · Feb 25, 2023 · PreprintPharmacology & Toxicology

Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds

E.-C. Wamhoff, L. Ronsard, J. Feldman, G. A. Knappe, B. M. Hauser, A. Romanov, E. Lam, K. St. Denis, J. Boucau, A. K. Barczak, A. B. Balazs, A. Schmidt, D. Lingwood, M. Bathe

This study shows DNA origami scaffolds enhance antibody responses to SARS-CoV-2 RBD without inducing immune memory against the scaffold itself, compared to protein-based VLPs.

bioRxiv · Aug 16, 2022Immunology

Controlling wireframe DNA origami nuclease degradation with minor groove binders

E.-C. Wamhoff, H. Huang, B. J. Read, E. Ginsburg, W. R. Schief, N. Farrell, D. J. Irvine, M. Bathe

This study demonstrates that minor groove binders can protect wireframe DNA origami from endonuclease degradation, enhancing their stability in biological environments.

bioRxiv · May 24, 2020Bioengineering

Bioproduction of single-stranded DNA from isogenic miniphage

T. R. Shepherd, R. R. Du, H. Huang, E.-C. Wamhoff, M. Bathe

This paper demonstrates the scalable production of custom-length single-stranded DNA (cssDNA) using engineered miniphage in E. coli, enabling applications in DNA origami and archival data storage.

bioRxiv · Jan 16, 2019 · PreprintBioengineering

A specific, glycomimetic Langerin ligand for human Langerhans cell targeting

E.-C. Wamhoff, J. Schulze, L. Bellmann, G. Bachem, F. F. Fuchsberger, J. Rademacher, M. Hermann, B. Del Frari, R. van Dalen, D. Hartmann, N. van Sorge, O. Seitz, P. Stoitzner, C. Rademacher

The paper develops a glycomimetic Langerin ligand for targeting Langerhans cells, enabling efficient antigen and adjuvant delivery for cancer vaccines.

bioRxiv · Mar 31, 2018Immunology

Discovery of BAZ2A Bromodomain Ligands

D. Spiliotopoulos, E.-C. Wamhoff, G. Lolli, C. Rademacher, A. Caflisch

The paper identifies BAZ2A bromodomain ligands through high-throughput screening and validates their binding using NMR and crystal structures.

bioRxiv · Jun 7, 2017Biochemistry