Dysregulated Skeletal Muscle Myosin Super-relaxation and Energetics in Type II Diabetes
C. T. Lewis, R. Moreno-Justicia, L. Savoure, E. Calvo, A. Bak, J. Laitila, R. A. E. Seaborne, S. Larsen, H. Iwamoto, M. Cefis, J. A. Morais, G. Gouspillou, J. Alegre-Cebollada, T. J. Hawke, J. Vazquez, , J. Ochala
This study investigates altered myosin super-relaxation and energy metabolism in type II diabetes using muscle biopsies and proteomic analyses, finding increased super-relaxation and reduced ATP demand.
bioRxiv · Jun 12, 2024 · PreprintCell Biology