Author

L. Lindfors

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:microscopy & imaging analysis· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Sabirsh· 3 shared A. Hoijer· 2 shared F. Hook· 2 shared M. Bickle· 2 shared M. Zerial· 2 shared N. Aliakbarinodehi· 2 shared P. Paramasivam· 2 shared S. Andersson· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiophysics

A. Sabirsh

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cellular and biophysical barriers to lipid nanoparticle mediated delivery of RNA to the cytosol

J. M. Johansson, H. Du Rietz, H. Hedlund, H. C. Eriksson, E. Oude Blenke, A. Pote, S. Harun, P. Nordenfelt, L. Lindfors, A. Wittrup

This study identifies multiple barriers to efficient cytosolic delivery of RNA by lipid nanoparticles, including endosomal sorting and membrane damage mechanisms.

bioRxiv · May 31, 2024Bioengineering

Time Resolved Inspection of Ionizable-Lipid Facilitated Lipid Nanoparticle Disintegration and Cargo Release at an Endosomal Membrane Mimic

N. Aliakbarinodehi, S. Niederkofler, E. Olsen, Y. Jing, G. Emilsson, M. Sjoberg, B. Agnarsson, L. Lindfors, F. Hook

This study uses TIRF imaging to examine pH-induced LNP fusion and mRNA release, showing delayed fusion onset and rapid cargo escape, with implications for optimizing mRNA delivery.

bioRxiv · Feb 22, 2024 · PreprintBiophysics

Time evolution of PEG-shedding and serum protein coronation determines the cell uptake kinetics and delivery of lipid nanoparticle formulated mRNA

A. Gallud, M. J. Munson, K. Liu, A. Idstrom, H. M. Barriga, S. Tabaei, N. Aliakbarinodehi, M. Ojansivu, Q. Lubart, J. J. Doutch, M. N. Holme, L. Evenas, L. Lindfors, M. M. Stevens, A. Collen, , E. K. Esbjorner

This study models protein corona formation on LNPs and identifies time-dependent steps that affect their uptake and mRNA delivery, showing that pre-incubation in serum can eliminate a lag-time.

bioRxiv · Aug 20, 2021 · PreprintBiophysics

Quantitative intracellular retention of delivered RNAs through optimized cell fixation and immuno-staining

P. Paramasivam, M. Stoter, E. Corradi, I. D. Costa, A. Hoijer, S. Bartesaghi, A. Sabirsh, L. Lindfors, M. Y. Arteta, P. Nordberg, S. Andersson, M.-L. Baudet, M. Bickle, M. Zerial

The paper optimizes cell fixation and immuno-staining to quantitatively retain and visualize exogenously delivered and endogenous nucleic acids in sub-cellular compartments.

bioRxiv · Jul 6, 2021Cell Biology

Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale

P. Paramasivam, C. Franke, M. Stoeter, A. Hoijer, S. Bartesaghi, A. Sabirsh, L. Lindfors, M. Yanez Arteta, A. Dahlen, A. Bak, S. Andersson, Y. Kalaidzidis, M. Bickle, M. Zerial

The paper visualizes mRNA escape from endosomal recycling tubules using super-resolution microscopy and identifies parameters affecting endosomal escape and cytotoxicity in human cells.

bioRxiv · Dec 18, 2020Bioengineering