M. Helm

Genome-informed trophic classification and functional characterization of virulence proteins from the maize tar spot pathogen Phyllachora maydis

This study uses a genome-informed approach to classify the trophic lifestyle of Phyllachora maydis and functionally characterize its effector proteins.

Comparative transcriptomic analysis of Zymoseptoria tritici reveals interaction-specific gene expression patterns during susceptible, resistant, and non-host interactions

This study compares gene expression in Zymoseptoria tritici during susceptible, resistant, and non-host interactions to identify interaction-specific gene expression patterns and candidate effectors.

Pseudomonas syringae pv. tomato DC3000 induces defense responses in diverse maize inbred lines

This study screens diverse maize inbreds for immune responses to Pseudomonas syringae pv. tomato DC3000, finding that some lines exhibit defense responses linked to effector recognition.

Uncovering the Infection Strategy of Phyllachora maydis during Maize Colonization: A Comprehensive Analysis

This study investigates how Phyllachora maydis infects and spreads in maize leaves using histological analysis of infected samples from multiple fields.

Analysis of cell death induction by the barley NLR immune receptor PBR1

This study investigates PBR1-mediated cell death in barley by showing that full-length PBR1 is required for hypersensitive response and that self-association occurs independently of AvrPphB.

Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer

This study identifies DECR2 as a key driver of treatment resistance in advanced prostate cancer by regulating lipid metabolism and cell cycle progression.

ACSM1 and ACSM3 regulate prostate cancer fatty acid metabolism to promote tumour growth and constrain ferroptosis

This study identifies ACSM1 and ACSM3 as AR-regulated factors that promote prostate cancer growth by enhancing fatty acid metabolism and suppressing ferroptosis.

ANTHRACNOSE RESISTANCE GENE2 confers fungal resistance in sorghum

This study identifies and characterizes ARG2, a gene conferring resistance to anthracnose disease in sorghum, showing its role in defense responses and growth advantages.

Candidate effector proteins from the maize tar spot pathogen Phyllachora maydis localize to diverse plant cell compartments

The paper identifies subcellular localization of effector proteins from the maize pathogen Phyllachora maydis using fluorescent tagging and microscopy.

Optimizing the PBS1 Decoy System to Confer Resistance to Potyvirus Infection in Arabidopsis and Soybean

This paper engineers a PBS1 decoy system to confer resistance to potyvirus infection in Arabidopsis and soybean by modifying PBS1 to be cleaved by viral proteases, resulting in complete resistance to TuMV and SMV.

Engineering a decoy substrate in soybean to enable recognition of the Soybean Mosaic Virus NIa protease

The paper shows that a soybean PBS1 decoy protein with a SMV NIa protease cleavage site triggers cell death and inhibits SMV spread, suggesting decoy engineering can be used in soybean and other crops.

Convergent evolution of effector protease recognition by Arabidopsis and barley

This study identifies convergent evolution of AvrPphB recognition in barley and wheat through Pbr1, a novel NLR gene that detects protease activity similar to Arabidopsis RPS5.