Efficacy of Parainfluenza Virus 5 (PIV5)-vectored Intranasal COVID-19 Vaccine as a Single Dose Vaccine and as a Booster against SARS-CoV-2 Variants
A. Beavis, Z. Li, K. Briggs, M. Diaz, E. Wrobel, M. Najera, D. An, N. Orr-Burks, J. Murray, P. Pati, J. Huang, J. J. Mousa, L. Hao, T.-Y. Hsiang, M. J. Gale, , B. He
This paper evaluates the immunogenicity and efficacy of PIV5-vectored COVID-19 vaccines against SARS-CoV-2 variants in hamsters, showing they induce strong neutralizing antibodies and provide protection as single doses or boosters.
bioRxiv · Jun 7, 2022 · PreprintMicrobiology