B. He

A Viral-Encoded Homologue of IPS-1 Modulates Innate Immune Signaling During KSHV Lytic Replication

This paper identifies a viral homologue of IPS-1, v-IPS-1, which modulates innate immune signaling during KSHV lytic replication by blocking type I interferon induction.

Comprehensive Biosynthetic Analysis of Human Microbiome Reveals Diverse Protective Ribosomal Peptides

This study identifies diverse ribosomally synthesized peptides in the human microbiome and shows some inhibit pathogens and reduce inflammation.

Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process

The paper constructs a transcriptomic atlas of immune cells across human lifespan and develops a biological age prediction model using scRNA-seq and bulk RNA-seq data.

Structural insights into physiological activation and antagonism of melanin-concentrating hormone receptor MCHR1

This study presents cryo-EM structures of MCHR1 in active and inactive states, revealing ligand recognition and activation mechanisms to aid drug development.

Mitochondrial uncoupler and retinoic acid synergistically induce differentiation and inhibit proliferation in neuroblastoma

A split crRNA with CRISPR-Cas12a enables highly sensitive, selective, and multiplexed detection of RNA and DNA

This paper develops a split CRISPR-Cas12a system for sensitive, selective, and multiplexed detection of RNA and DNA without reverse transcription, achieving low detection limits and improved specificity.

CLAIR: An integrated lipid database across multiple crop species

The paper constructs a comprehensive lipid metabolism gene database for nine oilseed crops by integrating multi-omics data and identifying 221 additional genes.

Continuous Tracking using Deep Learning-based Decoding for Non-invasive Brain-Computer Interface

This paper develops deep learning-based decoders for continuous brain-computer interface (BCI) control and shows they improve performance over time and outperform traditional methods in complex tasks.

β-catenin inhibition disrupts the homeostasis of osteogenic/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of femoral head

This study shows that β-catenin inhibition disrupts osteogenic/adipogenic differentiation in bone marrow mesenchymal cells, contributing to glucocorticoid-induced osteonecrosis of the femoral head.

TerC Proteins Function During Protein Secretion to Metalate Exoenzymes

The paper shows that TerC family proteins are involved in metalation of enzymes during secretion via the Sec pathway, specifically for manganese-dependent enzymes.

Detection and characterization of a novel bat filovirus (Dehong virus, DEHV) in fruit bats

The paper detects and characterizes a novel bat filovirus, Dehong virus (DEHV), from Rousettus leschenaultii bats, placing it phylogenetically between Dianlovirus and Marburgvirus.

Developmental Manganese Exposure Causes Lasting Attention Deficits Accompanied by Dysregulation of mTOR Signaling and Catecholaminergic Gene Expression in Brain Prefrontal Cortex

Fungal small RNAs ride in extracellular vesicles to enter plant cells through clathrin-mediated endocytosis

This study shows fungal small RNAs are secreted via extracellular vesicles and enter plant cells through clathrin-mediated endocytosis, using BcPLS1 as an EV biomarker.

Plasma cells in human pancreatic ductal adenocarcinoma secrete antibodies to self-antigens

The paper identifies auto-antibodies secreted by plasma cells in PDAC against self-antigens, suggesting a link between chronic inflammation and autoimmunity.

Integrating simultaneous motor imagery and spatial attention for EEG-BCI control

This paper integrates motor imagery and spatial attention paradigms for EEG-BCI control, showing improved performance over motor imagery alone in some users.

Comprehensive Multi-omics Analysis Reveals the Core Role of Glycerophospholipid Metabolism in Rheumatoid Arthritis Development

This study identifies glycerophospholipid metabolism as a key factor in rheumatoid arthritis development through multi-omics analysis of gut microbiota, metabolites, and gene expression.

Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

Botrytis cinerea small RNAs are associated with tomato AGO1 and silence tomato defense-related target genes supporting cross-kingdom RNAi

The paper reanalyzes existing data to show cross-kingdom RNAi between Botrytis cinerea and tomato, contradicting a previous study.

Low-intensity transcranial focused ultrasound suppresses pain by modulating pain processing brain circuits

This paper demonstrates that low-intensity transcranial focused ultrasound can suppress pain by modulating pain processing brain circuits in mouse models.

Personalized Deep Learning based Source Imaging Framework Improves the Imaging of Epileptic Sources from MEG Interictal Spikes

This paper introduces a personalized deep learning framework for imaging epileptic sources from MEG interictal spikes, showing improved accuracy and robustness in localization.

DeepAIR: a deep-learning framework for effective integration of sequence and 3D structure to enable adaptive immune receptor analysis

DeepAIR integrates sequence and 3D structure features of adaptive immune receptors to predict binding affinity and reactivity, outperforming existing methods on multiple tasks.

Efficacy of Parainfluenza Virus 5 (PIV5)-vectored Intranasal COVID-19 Vaccine as a Single Dose Vaccine and as a Booster against SARS-CoV-2 Variants

This paper evaluates the immunogenicity and efficacy of PIV5-vectored COVID-19 vaccines against SARS-CoV-2 variants in hamsters, showing they induce strong neutralizing antibodies and provide protection as single doses or boosters.

De-heterogeneity of the eukaryotic viral reference database (EVRD) improves the accuracy and efficiency of viromic analysis

The paper describes the purification of a viral reference database (EVRD) by removing contaminating sequences, improving accuracy and efficiency in viromic analysis.

ScRNA-Seq study of neutrophils reveals vast heterogeneity and breadth of inflammatory responses in severe COVID-19 patients

This study uses scRNA-Seq to analyze neutrophils in severe COVID-19 patients, revealing inflammatory heterogeneity and immune dysregulation linked to disease severity.

Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

Imaging the Extent and Location of Spatiotemporally Distributed Epileptiform Sources from MEG Measurements

This study applies the FAST-IRES algorithm to MEG data to image the location and extent of epileptiform sources in drug-resistant epilepsy patients.

Reprogramming the neuroblastoma epigenome with a mitochondrial uncoupler

This study uses a mitochondrial uncoupler to actively demethylate DNA in neuroblastoma cells, promoting differentiation and altering the epigenome.

Serine Starvation Silences Estrogen Receptor Signaling through Histone Hypoacetylation

The paper shows serine starvation reduces ER expression and histone acetylation in breast cancer cells, linking metabolic stress to chromatin changes and ER pathway inactivation.

A cationic motif in Engrailed-2 homeoprotein controls its internalization via selective cell-surface glycosaminoglycans interactions

The paper identifies a cationic motif in Engrailed-2 that mediates its internalization via interactions with heparan sulfate glycosaminoglycans.

RTN3 inhibits RIGI-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination

This study identifies RTN3 as a proresolving mediator that suppresses antiviral responses by inhibiting TRIM25-mediated K63-linked polyubiquitination of RIG-I, reducing neutrophil infiltration and inflammation.