J. Murray

Dichotomy in TCR V-domain dynamics modeled for binding the opposed inclined planes of pMHC-II and pMHC-I α-helices

The paper models TCR V-domain dynamics on pMHC-II and pMHC-I by analyzing rotational torque and sliding time, revealing a dichotomy in mobility between MHC classes.

Efficacy of Parainfluenza Virus 5 (PIV5)-vectored Intranasal COVID-19 Vaccine as a Single Dose Vaccine and as a Booster against SARS-CoV-2 Variants

This paper evaluates the immunogenicity and efficacy of PIV5-vectored COVID-19 vaccines against SARS-CoV-2 variants in hamsters, showing they induce strong neutralizing antibodies and provide protection as single doses or boosters.

Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: results of preclinical efficacy testing

This study evaluates two antivenoms as alternatives to SAIMR Polyvalent in Eswatini, finding they are equally or more effective against the most common snake venom but less effective against others.

The peptide GOLVEN10 controls nodule and lateral root organogenesis and positioning along the longitudinal root axis

The paper identifies GOLVEN10 peptide as a regulator of nodule and lateral root positioning and organogenesis in Medicago truncatula.

Structural basis for ultrapotent neutralization of human metapneumovirus

This study identifies a potent monoclonal antibody against hMPV and determines its structure, revealing a novel epitope for therapeutic development.

CDR3 binding chemistry controls TCR V-domain rotational probability and germline CDR2 'scanning' of polymorphic MHC

The paper investigates how CDR3 binding chemistry influences TCR V-domain rotational probability and CDR2 interactions with MHC-II, revealing a mechanism for TCR specificity.

Probenecid Inhibits SARS-CoV-2 Replication In Vivo and In Vitro

This study shows probenecid inhibits SARS-CoV-2 replication in mammalian cells and a hamster model, with achievable plasma concentrations supporting its potential clinical use.

Structure, immunogenicity, and conformation-dependent receptor binding of the post-fusion human metapneumovirus F protein

This study determines the structure of post-fusion hMPV B2 F protein, assesses its receptor binding and immunogenicity, and shows it induces neutralizing antibodies against multiple hMPV strains.

Disentangling the shark and ray trade in Indonesia to reconcile conservation with food security

This study examines shark and ray trade in Indonesia, revealing discrepancies between reported and actual exports and highlighting the role of domestic consumption in driving these gaps.

Novel inhibitors of E. coli lipoprotein diacylglyceryl transferase are insensitive to resistance caused by lpp deletion

The paper identifies Lgt inhibitors that remain effective against E. coli even when lpp is deleted, showing Lgt is a robust antibacterial target.

Are there Physical Linkages between Genes that have Synergistic Fitness Effects?

This study investigates the relationship between epistatic fitness effects and meiotic recombination rates using meta-analysis and simulations in Drosophila melanogaster.

Isolation and characterization of SARS-CoV-2 from the first US COVID-19 patient

The paper isolates and characterizes SARS-CoV-2 from the first US COVID-19 patient, showing high replication in Vero cells and depositing the strain for public use.

Protein-carbohydrate ingestion alters Vps34 cellular localization independent of changes in kinase activity in human skeletal muscle

This study shows that protein-carbohydrate ingestion in human skeletal muscle increases Vps34 translocation to the cell periphery and its co-localization with mTOR, without altering Vps34 kinase activity or preventing mTORC1 activation.

Lineage and stage-specific expressed CYCD7;1 coordinates the single symmetric division that creates stomatal guard cells

The paper identifies CYCD7;1 as a key regulator of the symmetric division that forms stomatal guard cells in Arabidopsis, showing its expression is limited to this specific developmental stage.