A. Bogorodskiy

This study develops GFP-inspired dyes to monitor ligand-induced conformational changes in GPCRs, showing fluorescence responses to agonists and allosteric modulators.

The paper develops twenty-two finely tuned flavin-binding fluorescent proteins for multicolor imaging by modifying the chromophore's spectral properties.

The paper identifies structural and mechanistic causes of spectral tuning in flavin-binding fluorescent proteins through mutagenesis, X-ray crystallography, and computational methods, enabling two-color microscopy.

This study uses smFRET to analyze the conformational dynamics of the A2A adenosine receptor, revealing slow and fast dynamics in different ligand-bound states.

This study develops a microinjection method to study mitochondrial protein import in living cells and finds that puromycin enhances import rates by releasing nascent polypeptides from ribosomes.