DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8+ T cells
Z. Yu, V. Sasidharan-Nair, A. Bonifacius, F. Khan, T. Buchta, M. Beckstette, J. Niemz, P. Hilgendorf, B. Pietzsch, P. Mausberg, A. Keller, C. S. Falk, D. S. Busch, M. Brinkmann, K. Schober, , J. Huehn
The paper identifies TBKBP1 as a key gene whose demethylation enhances cytotoxic activity in CMV-specific CD8+ T cells, suggesting it as a therapeutic target.
bioRxiv · Nov 6, 2023Immunology