Author

M. Beckstette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 3 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Organism:mouse· 2

Frequent Co-Authors

J. Huehn· 3 shared P. Dersch· 2 shared S. Floess· 2 shared A. Bonifacius· 1 shared A. K. Heroven· 1 shared A. Keller· 1 shared A. Nuss· 1 shared A.-E. Saliba· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersImmunology

J. Huehn

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

RNase-mediated reprogramming of Yersinia virulence

I. Meyer, M. Volk, I. Salto, T. Moesser, A.-S. Herbrüggen, M. Rohde, M. Beckstette, A. K. Heroven, P. Dersch

This study identifies RNase III and PNPase as key regulators of virulence gene expression in Yersinia pseudotuberculosis by modulating lcrF mRNA stability and translation.

bioRxiv · Jan 11, 2024 · PreprintMicrobiology

DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8+ T cells

Z. Yu, V. Sasidharan-Nair, A. Bonifacius, F. Khan, T. Buchta, M. Beckstette, J. Niemz, P. Hilgendorf, B. Pietzsch, P. Mausberg, A. Keller, C. S. Falk, D. S. Busch, M. Brinkmann, K. Schober, , J. Huehn

The paper identifies TBKBP1 as a key gene whose demethylation enhances cytotoxic activity in CMV-specific CD8+ T cells, suggesting it as a therapeutic target.

bioRxiv · Nov 6, 2023Immunology

The thymic microenvironment gradually modulates the phenotype of thymus-homing peripheral conventional dendritic cells

S. Herppich, M. Beckstette, J. Huehn

This study shows that peripheral conventional dendritic cells (cDCs) can acquire thymic characteristics when exposed to thymic microenvironment in vitro, including immunomodulatory gene expression and Treg cell-inducing capacity.

bioRxiv · Aug 27, 2021Immunology

Postnatal lymph node expansion of stromal progenitors towards reticular and CD34+ stromal cell subsets is determined by distinct transcriptional programs

J. Pezoldt, C. Wiechers, M. Litovchenko, M. Biocanin, M. Zou, K. Sitnik, M. Beckstette, W. Chen, V. Gardeux, S. Floess, M. Ebel, J. Russeil, P. Arampatzi, E. Vafardanejad, A.-E. Saliba, , J. Huehn

The paper identifies distinct transcriptional programs driving the expansion of stromal progenitors in mesenteric lymph nodes, revealing Irf3's role in FRC differentiation and microbiota-independent epigenomic signatures.

bioRxiv · Jun 6, 2021 · PreprintImmunology

The alarmone (p)ppGpp is part of the heat shock response of Bacillus subtilis

H. Schäfer, B. Beckert, W. Steinchen, A. Nuss, M. Beckstette, I. Hantke, P. Sudzinova, L. Krasny, V. Kaever, P. Dersch, G. Bange, D. Wilson, K. Turgay

This study shows that (p)ppGpp, a bacterial alarmone, mediates the heat shock response in B. subtilis by reducing translation and enhancing stress tolerance.

bioRxiv · Jul 1, 2019Microbiology