Diverse pathogens activate the host RIDD pathway to subvert BLOS1-directed immune defense
K. M. Wells, K. He, A. Pandey, A. Cabello, D. Zhang, J. Yang, G. Gomez, Y. Liu, H. Chang, X. Li, H. Zhang, L. F. da Costa, R. Metz, C. D. Johnson, C. L. Martin, , P. de Figueiredo
This study shows that pathogens like Brucella and coronavirus MHV exploit the RIDD pathway to degrade BLOS1, impairing lysosomal trafficking and enhancing their intracellular survival.
bioRxiv · Nov 4, 2021Microbiology