Cancer BiologybioRxiv
Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments
E. D. Tabdanov, N. J. Rodriguez-Merced, A. Cartagena-Rivera…·P. Provenzano
This study engineers T cells to improve 3D migration through tumor microenvironments by manipulating microtubule stability and contractility, showing enhanced migration in 3D matrices and tumors.
DOI 10.1038/s41467-021-22985-5