Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments
E. D. Tabdanov, N. J. Rodriguez-Merced, A. Cartagena-Rivera, V. Puram, M. Callaway, E. Ensminger, E. Pomeroy, K. Yamamoto, W. S. Lahr, B. R. Webber, B. Moriarity, A. Zhovmer, P. Provenzano
This study engineers T cells to improve 3D migration through tumor microenvironments by manipulating microtubule stability and contractility, showing enhanced migration in 3D matrices and tumors.
bioRxiv · Apr 21, 2020Cancer Biology