Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma
A. Ray, M. Callaway, N. Rodriguez-Merced, A. Crampton, M. Carlson, K. Emme, E. Ensminger, A. Kinne, J. Schrope, H. Rasmussen, H. Jiang, D. DeNardo, D. Wood, P. Provenzano
This study shows that stromal collagen structures in pancreatic ductal adenocarcinoma promote early dissemination from pre-malignant lesions and ongoing invasion, suggesting FAK inhibition or stroma normalization could limit metastasis.
bioRxiv · Feb 19, 2021Cancer Biology