Dampened PI3K/AKT signaling contributes to cancer resistance of the naked mole rat
J. Zhao, X. Tian, Y. Zhu, Z. Zhang, E. Rydkina, Y. Yuan, H. Zhang, B. Roy, A. Cornwell, E. Nevo, X. Shang, R. Huang, K. Kristiansen, A. Seluanov, X. Fang, V. Gorbunova
This study compares transcriptional responses to oncogenes in cancer-resistant and -prone species, finding that naked mole rat cells resist Ras-induced changes due to dampened PI3K/AKT signaling.
bioRxiv · Feb 27, 2020 · PreprintCancer Biology