Author

X. Shang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Microbiology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 6 Research Focus:cell type annotation· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2

Frequent Co-Authors

G. Wang· 2 shared L. Wang· 2 shared R. Huang· 2 shared S. Shen· 2 shared W. Jia· 2 shared W. Liu· 2 shared w. yang· 2 shared X. Fang· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

G. Wang

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The effects of L-carnitine and fructose in improved Ham's F10 on sperm culture in idiopathic severe asthenospermia within 24h

D. Chang, F. Li, Y. Kang, Y. Yang, F. Kong, W. Jiang, D. Wang, Z. Cao, L. Xu, C. Huang, Y. Kang, X. Shang, B. Zhang

This study evaluates the effects of L-carnitine and fructose in modified Ham's F10 medium on sperm motility in idiopathic severe asthenospermia patients within 24h, finding improved viability at specific concentrations and temperature.

bioRxiv · Jun 16, 2024Biochemistry

Targeting GFPT2 to reinvigorate immunotherapy in EGFR-mutated NSCLC

L. Ao, W. Jia, Q. Gong, J. Cui, J. Wang, Y. Yu, C. Fu, H. Li, J. Wei, R. Wang, F. Wang, X. Shang, Y. Li, S. Fang, G. Wang, , J. Liu

This study identifies GFPT2 as a metabolic checkpoint in EGFR-mutated NSCLC that promotes immune evasion, and shows that targeting GFPT2 enhances PD-1 blockade therapy.

bioRxiv · Mar 1, 2024 · PreprintCancer Biology

Structural insights into specific recognition of PTENα/β-NTE by WDR5 in cancer progression

X. Huang, C. Zhang, X. Shang, Y. Chen, Q. Xiao, Z. Wei, G. Wang, X. Zhen, G. Xu, J. Min, S. Shen, Y. Liu

The paper determines the crystal structure of PTEN-NTE bound to WDR5, revealing a specific binding motif that promotes tumor growth and suggests WDR5 inhibitors as potential cancer therapies.

bioRxiv · Dec 9, 2023 · PreprintCancer Biology

CTLA-4 tail fusion enhances CAR-T anti-tumor immunity

X. Zhou, H. Cao, S.-Y. Fang, R. D. Chow, K. Tang, M. Majety, M. Bai, M. B. Dong, P. A. Renauer, X. Shang, K. Suzuki, A. Levchenko, S. Chen

This study enhances CAR-T cell efficacy by fusing CTLA-4 cytoplasmic tails to CARs, improving anti-tumor responses in a leukemia model.

bioRxiv · Mar 14, 2023 · PreprintImmunology

5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes

M. Liu, G. Guo, P. Qian, J. Mu, B. Lu, X. He, X. Shang, G. Yang, S. Shen, W. Liu, L. Wang, L. Gu, Q. Mu, X. Yu, Y. Zhao, , Q. Zhang

This study identifies m5C mRNA modifications mediated by Plasmodium NSUN2 as critical for transcript stability and gametocyte development in malaria parasites.

bioRxiv · Jun 6, 2021Microbiology

Dampened PI3K/AKT signaling contributes to cancer resistance of the naked mole rat

J. Zhao, X. Tian, Y. Zhu, Z. Zhang, E. Rydkina, Y. Yuan, H. Zhang, B. Roy, A. Cornwell, E. Nevo, X. Shang, R. Huang, K. Kristiansen, A. Seluanov, X. Fang, V. Gorbunova

This study compares transcriptional responses to oncogenes in cancer-resistant and -prone species, finding that naked mole rat cells resist Ras-induced changes due to dampened PI3K/AKT signaling.

bioRxiv · Feb 27, 2020 · PreprintCancer Biology

Changes in the expression of interleukin-10 in myocardial infarction and its relationship with macrophage activation and cell apoptosis

w. yang, s. li, y. zhao, y. sun, y. huang, z. diao, c. xing, f. yang, w. liu, x. zhao, x. shang

This study examines changes in IL-10 expression in myocardial infarction and its association with macrophage activation and cardiomyocyte apoptosis over time.

bioRxiv · Sep 30, 2019Cell Biology

A Clostridia-rich microbiota contributes to increased excretion of bile acids in diarrhea-predominant irritable bowel syndrome

L. Zhao, W. Yang, Y. Chen, F. Huang, L. Lu, C. Lin, T. Huang, Z. Ning, L. Zhai, L. L. Zhong, W. Lam, Z. Yang, X. Zhang, C. Cheng, L. Han, , Z. Bian

This study identifies a Clostridia-rich microbiota as a contributor to excessive bile acid excretion in IBS-D patients through metagenomic and metabolomic analyses.

bioRxiv · May 12, 2019Microbiology

ARID1a protects against steatosis and insulin resistance via PPARalpha-mediated fatty acid oxidation

y. qu, c. deng, q. luo, x. Shang, j. Wu, Y. Shi, L. Wang, Z.-G. Han

This study shows that Arid1a deficiency in mice leads to hepatic steatosis and insulin resistance by impairing fatty acid oxidation through PPARalpha.

bioRxiv · Jan 9, 2019 · PreprintCell Biology