C. Bakal

PARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-kappa B-regulated immune response.

This paper identifies PARP inhibitors as sensitizers for oncolytic reovirus by enhancing DISC-mediated apoptosis and NF-kappa B-driven immune responses.

Biocompatibility characterisation of CMOS-based Lab-on-Chip electrochemical sensors for in vitro cancer cell culture applications

This study evaluates the biocompatibility of Si3N4-coated CMOS-based Lab-on-Chip sensors for cancer cell culture, showing reduced cell adhesion and altered mechano-responsiveness compared to standard plastic.

A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis

This study identifies a Nav1.5-dependent feedback loop that links extracellular acidification to Na+ influx, promoting breast cancer metastasis.

Re-engineering of TNFα-NF-κB signalling dynamics in cancer cells using pathogenic E. coli effectors

This study uses bacterial effectors to manipulate NF-κB signalling in cancer cells, showing that combining Tir, NleE, and TNF can eliminate 95% of pancreatic cancer cells with minimal NF-κB activation.

Coupling of Nuclear Translocation to Cell Size Promotes Robustness to Fluctuations in YAP/TAZ Concentration

The paper shows that nuclear YAP/TAZ concentration remains stable during cell cycle despite whole-cell dilution, due to coupling with cell size and nuclear transport processes.

Actin networks modulate heterogenous NF-κB dynamics in response to TNFα

The paper investigates how actin networks influence NF-κB dynamics in PDAC cells, identifying feedback loops involving RELA, NUAK2, ARHGAP31, and RELB.

Environmentally dependent and independent control of cell shape determination by Rho GTPase regulators in melanoma

This study compares cell shape determination in 2D and 3D environments using melanoma cells and identifies Rho GTPase regulators that modulate shape changes in response to environmental cues.

Robust optical autofocus system utilizing neural networks trained for extended range and time-course and automated multiwell plate imaging including single molecule localization microscopy

The paper develops a neural network-based autofocus system for microscopy, improving accuracy and range for long-term and multiwell plate imaging.

PERK-dependent reciprocal crosstalk between ER and non-centrosomal microtubules coordinates ER architecture and cell shape

The paper shows PERK regulates ER remodeling and cell shape by interacting with non-centrosomal microtubules during stress.

Dual-view oblique plane microscopy (dOPM)

This paper introduces a new dual-view oblique plane microscopy technique that improves resolution and reduces shadow artefacts in multi-cellular spheroid imaging.

Cyclin A triggers Mitosis either via Greatwall or Cyclin B

This study shows Cyclin A can trigger mitosis through Greatwall or Cyclin B by regulating Cdk1 activity and phosphorylation of mitotic substrates.

A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division

A high-content RNAi screen identifies lncRNAs involved in cell division, revealing linc00899's role in regulating microtubule dynamics through suppression of TPPP/p25.

Spatial Organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins

The paper characterizes RhoGEF/RhoGAP substrate specificities, localization, and interactomes to reveal their role in spatially organizing Rho signaling.