Author

A. E. Prota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

M. O. Steinmetz· 2 shared A. Akhmanova· 1 shared A. Rai· 1 shared D. Lucena-Agell· 1 shared F. Josa-Prado· 1 shared G. Menchon· 1 shared J. Estevez-Gallego· 1 shared J. F. Diaz· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

M. O. Steinmetz

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Author profile →

2 papers

Recent·Most cited

Structural insight into the stabilization of microtubules by taxanes

A. E. Prota, D. Lucena-Agell, Y. Ma, J. Estevez-Gallego, S. Li, K. Bargsten, F. Josa-Prado, J. M. Andreu, K.-H. Altmann, N. Gaillard, S. Kamimura, T. Muehlethaler, M. A. Oliva, M. O. Steinmetz, W.-S. Fang, J. F. Diaz

This study determines the crystal structures of taxane-tubulin complexes and uses simulations to elucidate how taxanes stabilize microtubules through conformational changes and ligand binding.

bioRxiv · Jul 20, 2021Biophysics

Pharmaceutical-grade Rigosertib is a Microtubule-destabilizing Agent

M. Jost, Y. Chen, L. A. Gilbert, M. A. Horlbeck, L. Krenning, G. Menchon, A. Rai, M. Y. Cho, J. J. Stern, A. E. Prota, M. Kampmann, A. Akhmanova, M. O. Steinmetz, M. E. Tanenbaum, J. S. Weissman

This paper shows pharmaceutical-grade rigosertib, with high purity, causes microtubule destabilization in cells, confirming its mechanism of action against cancer cells.

bioRxiv · Jan 28, 2020Cancer Biology