Author

M. A. Horlbeck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

J. S. Weissman· 4 shared M. Jost· 3 shared M. E. Tanenbaum· 2 shared M. Kampmann· 2 shared A. Akhmanova· 1 shared A. E. Prota· 1 shared A. Rai· 1 shared B. S. Phinney· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersCell Biology

J. S. Weissman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cell BiologybioRxivFeb 16, 2021

Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

M. Le Vasseur, J. R. Friedman, M. Jost…·J. Nunnari

DOI 10.7554/elife.67624

humanexperimental assay

𝕏 PostBluesky

Cell BiologybioRxivJun 30, 2020

High-content Imaging-based Pooled CRISPR Screens in Mammalian Cells

X. Yan, N. Stuurman, S. A. Ribeiro…·R. Vale

The paper develops an imaging-based CRISPR screening method called optical enrichment to identify genes affecting nuclear size, identifying 14 hits from 6092 sgRNAs.

DOI 10.1083/jcb.202008158

mouseflow cytometry

𝕏 PostBluesky

Cancer BiologybioRxivJan 28, 2020

Pharmaceutical-grade Rigosertib is a Microtubule-destabilizing Agent

M. Jost, Y. Chen, L. A. Gilbert…·J. S. Weissman

This paper shows pharmaceutical-grade rigosertib, with high purity, causes microtubule destabilization in cells, confirming its mechanism of action against cancer cells.

DOI 10.1016/j.molcel.2020.06.008

humanproteomics

𝕏 PostBluesky

BiochemistrybioRxivMar 27, 2018

Identification and characterization of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

E. K. O'Shea, Z. Yu, L. E. Surface…·J. S. Weissman

The paper identifies SLC37A3 as a transporter required for nitrogen-containing bisphosphonates (N-BPs) to enter the cytosol, revealing their mechanism of action.

DOI 10.7554/elife.36620

humangenetic perturbation / CRISPR

𝕏 PostBluesky