Cancer BiologybioRxivPreprint
ASCL1-ERK1/2 Axis: ASCL1 restrains ERK1/2 via the dual specificity phosphatase DUSP6 to promote survival of a subset of neuroendocrine lung cancers
A. Martin-Vega, S. Earnest, A. Augustyn…·M. H. Cobb
This study identifies the ASCL1-DUSP6-ERK1/2 axis as a mechanism promoting survival in neuroendocrine lung cancers, suggesting DUSP6 as a potential therapeutic target.
DOI 10.1101/2023.06.15.545148