L. Cai

Glycosaminoglycan-mediated lipoprotein uptake protects cancer cells from ferroptosis

This study identifies glycosaminoglycan-mediated lipoprotein uptake as a mechanism by which cancer cells resist ferroptosis and lipid oxidative stress.

A Lung Cancer Mouse Model Database

The paper establishes a database of lung cancer mouse models to improve data comparison and translational relevance by aligning mouse mutations with human lung cancer mutations.

Bottlebrush polyethylene glycol nanocarriers translocate across human airway epithelium via molecular architecture enhanced endocytosis

This paper demonstrates that bottlebrush PEG nanocarriers can translocate across human airway epithelium via enhanced endocytosis due to their unique molecular architecture.

Voxelated bioprinting of modular double-network bio-ink droplets

This paper introduces a voxelated bioprinting method to create double-network hydrogel droplets with precise 3D assembly and mechanical properties.

A gel-coated air-liquid-interface culture system with tunable substrate stiffness matching healthy and diseased lung tissues

This paper introduces a gel-coated air-liquid-interface culture system that mimics the stiffness of healthy and fibrotic lung tissues, showing enhanced cell migration on pathological stiffness.

Association between the rifampicin resistance mutations and rifabutin susceptibility in Mycobacterium tuberculosis: a meta-analysis

This study identifies RIF-resistance mutations in M. tuberculosis associated with rifabutin susceptibility through a meta-analysis of 25 studies.

Modeling of enzyme-mediated glucose release to facilitate continuous feed in miniaturized cultivations

The paper develops a mathematical model to control glucose release via enzyme-mediated cleavage in miniaturized cultivations, enabling precise growth rate regulation without complex equipment.

Electron transport inhibition increases cellular dependence on purine transport and salvage

This study shows that ETC inhibition in cancer cells increases reliance on purine salvage and transport, revealing a metabolic vulnerability in tumors with low oxidative metabolism.

The contribution of plant life and growth forms to global gradients of vascular plant diversity

The paper quantifies how different plant forms contribute to global vascular plant diversity gradients and identifies environmental and phylogenetic factors shaping their distribution.

Association of NOTCH3 with Elastic Fiber Dispersion in the Infrarenal Abdominal Aorta of Cynomolgus Monkeys

The paper examines regional heterogeneity in aortas of cynomolgus monkeys, finding increased NOTCH3 and dispersed elastic fibers in the infrarenal region.

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma

This study identifies BRD9 as a key regulator of pancreatic cancer stem cell stemness and tumorigenesis, showing that its inhibition reduces CSC self-renewal and enhances chemotherapy response.

Mitochondrial metabolism in primary and metastatic human kidney cancers

This study investigates mitochondrial metabolism in kidney cancers, finding that primary tumors have suppressed mitochondrial function while metastases show enhanced TCA cycle labeling.

Phylogenetic endemism of the world's seed plants

This study quantifies phylogenetic endemism in seed plants worldwide, identifying drivers and centers of neo- and paleoendemism, and highlights conservation priorities.

Acellular Cartilage-Bone Allografts Restore Structure, Mechanics, and Surface Properties In Vivo, but Limit Recellularization and Integrative Repair

This study shows acellular osteochondral allografts improve cartilage repair in sheep after 6 months but limit recellularization and long-term integration.

Brief report: Reclassifying SCLC-Y as SMARCA4 deficient malignancies - resolving the controversy

The paper reclassifies YAP1-expressing SCLC-Y as SMARCA4-deficient malignancies, showing they lack SCLC features and instead resemble SMARCA4-deficient tumors.

All-Aqueous Printing of Viscoelastic Droplets in Yield-Stress Fluids

This paper identifies key parameters and stages for all-aqueous printing of viscoelastic droplets in yield-stress fluids, providing a framework for precise 3D bioprinting.

Data-Driven Design of Protein-Derived Peptide Multiplexes for Biomimetic Detection of Exhaled Breath VOC Profiles

The paper designs peptide-based sensors using machine learning and OBPs to detect VOCs in exhaled breath for disease monitoring.

A cryptic transactivation domain of EZH2 binds AR and AR's splice variant promoting oncogene activation and tumorous transformation

This study identifies a cryptic transactivation domain of EZH2 that binds AR and AR-V7, promoting oncogene activation and tumorous transformation, and shows that targeting this interaction with a PROTAC reduces tumor growth.

The small cell lung cancer neuroendocrine transdifferentiation explorer

This study curates genes associated with NE transdifferentiation in SCLC and compares transcriptomic changes across multiple datasets to create a web tool for exploring NE transdifferentiation in SCLC and NBL.

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

This paper develops an MS method to analyze all 16 aspartate and 32 glutamate isotopomers with high sensitivity, enabling pathway discrimination and metabolic heterogeneity studies in human tumors.

Glutamine metabolism modulates chondrocyte inflammatory response

This study shows that glutamine metabolism in chondrocytes influences inflammatory responses and autophagy, with glutamine deprivation reducing inflammation by inhibiting NF-κB.

Development and application of an uncapped mRNA platform

The paper develops an uncapped mRNA platform and demonstrates its effectiveness in inducing immune responses and protein expression in vitro and in vivo.

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge

This study shows that peptide-poloxamine-DNA nanoparticles provide complete protection against lethal SARS-CoV-2 challenge through robust mucosal immunity.

Modeling clonal evolution and oncogenic dependency in vivo in the context of hematopoietic transformation

This study models clonal evolution and oncogenic dependency in hematopoietic transformation using reversible mutagenesis and allelic frameworks.

Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms

This study shows that reversible activation of Jak2V617F in a mouse model demonstrates its essential role in myeloproliferative neoplasms and highlights the therapeutic potential of mutant-specific JAK2 inhibition.

Evolution and Diversification Dynamics of Butterflies

This study constructs a comprehensive phylogenomic tree of butterflies and finds they originated in the Americas, diversified in the Paleotropics, and followed a 'cradle' pattern of dispersal.

Machine learning improves global models of plant diversity

The paper uses machine learning and statistical models to predict global plant diversity patterns based on environmental data, achieving high accuracy for species and phylogenetic richness.

An intergeneric recombinant geminivirus causes soybean stay-green disease

This paper identifies a novel intergeneric recombinant geminivirus as the cause of soybean stay-green disease, showing it induces symptoms and can be detected in seed coats but not seeds.

Single-cell RNA-seq analysis reveals lung epithelial cell-specific contributions of Tet1 to allergic inflammation

This study uses single-cell RNA-seq to show that Tet1 deletion in lung epithelial cells promotes allergen-induced inflammation by altering transcriptomic networks and cell type composition.

PhyloHerb: A phylogenomic pipeline for processing genome skimming data for plants

PhyloHerb processes genome skimming data to assemble phylogenomic datasets, demonstrating accuracy with fragmented assemblies from herbarium specimens.