A. Ghoshal

Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

Synergistic phenotypic shifts during domestication promote plankton-to-biofilm transition in purple sulfur bacterium Chromatium okenii

This study shows that domestication of Chromatium okenii leads to synergistic phenotypic shifts that suppress motility and promote a transition to a sessile biofilm state.

Phytoplankton tune local pH to actively modulate circadian swimming behavior

This study shows that phytoplankton actively regulate local pH to create distinct gravitactic sub-populations, leading to irregular diel vertical migration patterns.

Active reconfiguration of cytoplasmic lipid droplets governs migration of nutrient-limited phytoplankton

This study shows that phytoplankton use lipid droplets to biomechanically regulate migration in nutrient-limited environments.

Zinc2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro.

This study shows that zinc ions inhibit SARS-CoV-2 main protease and viral replication in vitro, with structural evidence supporting the mechanism.

Fright and Fight: Role of predation and competition on mate search tactics of wild male zebrafish

This study examines how predation and competition influence mate search tactics in wild male zebrafish, finding that numerical cognition affects mating decisions and that social cues shape association preferences.

What drives male association tendencies in wild zebrafish? Role of female and vegetation densities

The paper investigates how female and vegetation densities influence mate association tactics in wild zebrafish, finding that vegetation cover has a stronger impact than female density.