Author

R. Halder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Cancer Biology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:metagenomics· 5 Approach:statistical model· 5 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:benchmarking· 2 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2

Frequent Co-Authors

P. May· 5 shared P. Wilmes· 5 shared B. J. Kunath· 4 shared C. C. Laczny· 3 shared C. Martin-Gallausiaux· 2 shared L. de Nies· 2 shared P. T. Queiros· 2 shared S. B. Busi· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersMicrobiology

P. May

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Oncogenic drivers dictate immune control of acute myeloid leukemia.

R. J. Austin, J. Straube, R. Halder, Y. Janardhanan, C. Bruedigam, M. Witkowski, L. Cooper, A. Porter, M. Braun, F. Souza-Fonseca-Guimaraes, S. A. Minnie, E. Cooper, S. Jacquelin, A. Song, T. Bald, , M. J. Bywater

This study shows that specific AML oncogenes influence immune responses and escape mechanisms, with NrasG12D promoting anti-leukemia immunity that can be counteracted by Myc.

bioRxiv · Feb 8, 2023Cancer Biology

Formate Promotes Invasion and Metastasis by Activating Fatty Acid Synthesis and Matrix Metalloproteinases

C. Delbrouck, N. Kiweler, V. Pozdeev, L. Neises, A. Oudin, A. Schuster, A. F. D'Herouel, R. Shen, R. Halder, A. Lesur, C. Ogris, N. Lorenz, C. Jaeger, M. Ronellenfitsch, M. Piraud, , J. Meiser

bioRxiv · Jan 23, 2023 · PreprintCancer Biology

Altered infective competence of the human gut microbiome in COVID-19

L. de Nies, V. Galata, C. Martin-Gallausiaux, M. Despotovic, S. B. Busi, C. J. Snoeck, L. Delacour, D. P. Budagavi, C. C. Laczny, J. Habier, P.-C. Lupu, R. Halder, J. V. Fritz, T. Marques, E. Sandt, , P. Wilmes

This study identifies increased virulence factors and antimicrobial resistance genes in the gut microbiome of COVID-19 patients, suggesting heightened infective competence.

bioRxiv · Oct 20, 2022 · PreprintMicrobiology

Forecasting of a complex microbial community using meta-omics

F. Delogu, B. J. Kunath, P. Queiros, R. Halder, L. A. Lebrun, P. B. Pope, P. May, S. Widder, E. E. L. Muller, P. Wilmes

The paper forecasts microbial community dynamics in a wastewater treatment plant using longitudinal meta-omics data and temporal signals, achieving accurate predictions of gene abundance and expression.

bioRxiv · Oct 19, 2022 · PreprintMicrobiology

Alterations of oral microbiota and impact on the gut microbiome in type 1 diabetes mellitus revealed by multi-omic analysis

B. J. Kunath, O. Hickl, P. T. Queiros, C. Martin-Gallausiaux, L. Lebrun, R. Halder, C. C. Laczny, T. S. Schmidt, D. Becher, A. Heintz-Buschart, C. Debeaufort, P. Borg, P. May, P. Wilmes

This study identifies oral microbiota changes in T1DM linked to gut microbiome alterations through multi-omic analysis of saliva and stool samples.

bioRxiv · Feb 13, 2022 · PreprintMicrobiology

Subpopulations of soluble, misfolded proteins commonly bypass chaperones: How it happens at the molecular level

R. Halder, D. A. Nissley, I. Sitarik, E. P. O'Brien

The paper shows that some soluble, misfolded proteins evade chaperones by being structurally similar to native states, leading to long-term misfolding.

bioRxiv · Aug 18, 2021 · PreprintBiophysics

Zinc2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro.

L. Panchariya, W. A. Khan, S. Kuila, K. Sonkar, S. Sahoo, A. Ghoshal, A. Kumar, D. K. Verma, A. Hasan, S. Das, J. K. Thakur, R. Halder, S. Sunil, A. Arulandu

This study shows that zinc ions inhibit SARS-CoV-2 main protease and viral replication in vitro, with structural evidence supporting the mechanism.

bioRxiv · Jun 15, 2021Biochemistry

Synergistic effect of short- and long-read sequencing on functional meta-omics

V. Galata, S. B. Busi, B. J. Kunath, L. de Nies, M. Calusinska, R. Halder, P. May, P. Wilmes, C. C. Laczny

The paper evaluates short-read, long-read, and hybrid metagenomic assembly methods on complex samples and proposes a reference-independent approach using multi-omic integration for microbiome analysis.

bioRxiv · Apr 22, 2021Microbiology

Critical Assessment of Metaproteome Investigation (CAMPI): a Multi-Lab Comparison of Established Workflows

T. Van Den Bossche, B. J. Kunath, K. Schallert, S. S. Schäpe, P. E. Abraham, J. Armengaud, M. O. Arntzen, A. Bassignani, D. Benndorf, S. Fuchs, R. J. Giannone, T. J. Griffin, L. H. Hagen, R. Halder, C. Henry, , Marte

CAMPI evaluates metaproteomic workflows across labs, finding sample processing drives peptide variability while workflows yield similar functional profiles.

bioRxiv · Mar 5, 2021Microbiology