Author

A. H. Settle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

B. Y. Winer· 3 shared M. Huse· 3 shared D. Vorselen· 2 shared J. S. A. Perry· 2 shared M. Galiano· 2 shared Y. Y. Wong· 2 shared A. M. Yakimov· 1 shared A. Sawh· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCell Biology

B. Y. Winer

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

A. H. Settle, B. Y. Winer, M. M. de Jesus, L. Seeman, Z. Wang, E. Chan, Y. Romin, L. Zhuoning, M. M. Miele, R. C. Hendrickson, D. Vorselen, J. S. A. Perry, M. Huse

This study shows that β2 integrins regulate macrophage phagocytosis based on cargo rigidity, acting as a mechanical checkpoint to control engulfment strategies.

bioRxiv · Feb 20, 2024Cell Biology

Plasma membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells

B. Y. Winer, A. H. Settle, A. M. Yakimov, C. Jeronimo, T. Lazarovt, M. Tipping, M. Saoi, A. Sawh, A.-L. L. Sepp, M. Galiano, J. S. A. Perry, Y. Y. Wong, F. Geissmann, J. Cross, T. Zhou, , M. Huse

This study shows that plasma membrane abundance regulates phagocytic capacity and post-phagocytic migration in myeloid cells, with G{beta}4 deficiency leading to increased phagocytosis and altered trafficking.

bioRxiv · Sep 12, 2023 · PreprintCell Biology

Topographical analysis of immune cell interactions reveals a biomechanical signature for immune cytolysis

M. de Jesus, A. H. Settle, D. Vorselen, T. K. Gaetjens, M. Galiano, Y. Y. Wong, T.-M. Fu, E. Santosa, B. Y. Winer, F. Tamzalit, M. S. Wang, Z. Bao, J. C. Sun, P. Shah, J. A. Theriot, , M. Huse

The paper analyzes immune cell interactions using traction force microscopy to identify biomechanical features associated with cytotoxic T cell activity.

bioRxiv · Apr 16, 2023 · PreprintImmunology