M. Huse

β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

This study shows that β2 integrins regulate macrophage phagocytosis based on cargo rigidity, acting as a mechanical checkpoint to control engulfment strategies.

Plasma membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells

This study shows that plasma membrane abundance regulates phagocytic capacity and post-phagocytic migration in myeloid cells, with G{beta}4 deficiency leading to increased phagocytosis and altered trafficking.

Topographical analysis of immune cell interactions reveals a biomechanical signature for immune cytolysis

The paper analyzes immune cell interactions using traction force microscopy to identify biomechanical features associated with cytotoxic T cell activity.

Apoptotic contraction drives target cell release by cytotoxic T cells

This study identifies apoptotic contraction as a mechanism driving CTL dissociation and target cell release.

Mechanically active integrins direct cytotoxic secretion at the immune synapse

This study identifies integrin mechanotransduction as essential for directing cytotoxic secretion at the immune synapse, showing that mechanical forces from LFA-1 guide lytic granule fusion and cytotoxicity.

Cytotoxic lymphocytes use mechanosurveillance to target biophysical vulnerabilities in cancer

This study shows that cancer cells with increased MRTF signaling are more rigid and vulnerable to immune cells, revealing a mechanical aspect of immunosurveillance.

Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing

This study shows that centrioles affect the capacity but not the specificity of cytotoxic T cell killing by impacting granule biogenesis and actin remodeling, not granule polarization.

Superresolved microparticle traction force microscopy reveals subcellular force patterns in immune cell-target interactions

This paper develops a superresolution traction force microscopy method to measure subcellular forces in immune cell-target interactions without using embedded tracers.

Actin clearance promotes polarized dynein accumulation at the immunological synapse

This study shows that actin clearance is required for dynein accumulation at the immunological synapse, which drives centrosome reorientation in T cells.

Interfacial actin protrusions mechanically potentiate killing by cytotoxic T cells

Cytotoxic T cells use actin-rich protrusions at immunological synapses to enhance perforin and granzyme-mediated killing of target cells.