Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death by Activating a TGFbeta3/TFEB/STAT3 Pathway Early during Mammary Gland Involution
J. JEONG, J. Lee, G. Talaia, W. Kim, J. Song, J. Hong, K. Yoo, D. Gonzalez, D. Athonvarangkul, J. Shin, P. Dann, A. Haberman, L. K. Kim, S. Ferguson, J. Choi, J. Wysolmerski
The paper shows that intracellular calcium, triggered by milk stasis, activates STAT3 via SOCS3 degradation and TFEB, leading to lysosome-dependent cell death during mammary gland involution.
bioRxiv · May 17, 2022 · PreprintCell Biology