Author

A. Hickey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. A. Besson· 1 shared A. Annis· 1 shared A. Ragsdale· 1 shared A. Schmalstig· 1 shared B. Jermain· 1 shared B. Miller· 1 shared B. O. Diekman· 1 shared C. Xander· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperEvolutionary Biology

A. A. Besson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pharmacokinetic considerations for optimizing inhaled spray-dried pyrazinoic acid formulations

S. B. Yeshwante, P. Hanafin, B. Miller, L. Rank, S. Murcia, C. Xander, A. Annis, V. Baxter, E. Anderson, B. Jermain, R. Konicki, A. Schmalstig, I. Stewart, M. Braunstein, A. Hickey, G. G. Rao

This study develops and evaluates inhaled POA formulations to improve TB treatment by enhancing pulmonary exposure and efficacy against pncA-mutant Mtb.

bioRxiv · Apr 1, 2023Pharmacology & Toxicology

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics

E. L. Doherty, W. Y. Aw, E. C. Warren, M. Hockenberry, G. Krohn, S. D. Howell, B. O. Diekman, W. R. Legant, H. T. Nia, A. Hickey, W. J. Polacheck

The paper shows that COL3A1 mutations alter ECM composition and mechanical properties, affecting endothelial cell migration and suggesting ECM mechanics as a prognostic indicator for vEDS.

bioRxiv · Oct 16, 2022Bioengineering

Effects of altered cellular ultrastructure on energy metabolism in diabetic cardiomyopathy - an in-silico study

S. Ghosh, G. Guglielmi, I. Orfanidis, F. Spill, A. Hickey, E. Hanssen, V. Rajagopal

This study uses computational modeling to show that disorganized mitochondrial and myofibrillar arrangement in diabetic cardiomyocytes leads to spatial variation in ADP/ATP ratios and increased inorganic phosphate concentration.

bioRxiv · May 22, 2022Cell Biology

Paternal hypoxia exposure primes offspring for increased hypoxia resistance

A. Ragsdale, O. Ortega-Recalde, L. Dutoit, A. A. Besson, J. H. Z. Chia, T. King, S. Nakagawa, A. Hickey, N. Gemmell, T. Hore, S. Johnson

This study shows that paternal hypoxia exposure increases offspring hypoxia tolerance through upregulated hemoglobin genes, without detectable methylation changes.

bioRxiv · Dec 9, 2020Evolutionary Biology