E. Anderson

Lethal COVID-19 Associates With RAAS-Induced Inflammation For Multiple Organ Damage Including Mediastinal Lymph Nodes

This study identifies non-canonical genes linked to RAAS overactivation in lethal COVID-19, causing multi-organ damage and mediastinal lymph node dysfunction.

KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo

This study shows that wild-type KRAS suppresses tumour growth and metastasis in KRAS mutant colorectal cancer while enhancing resistance to MEK inhibition.

Microbiome variability of mosquito lines is consistent over time and across environments

The paper shows that mosquito lines maintain distinct microbiomes across different environments, indicating host genetics and environment both shape microbiome composition.

Pharmacokinetic considerations for optimizing inhaled spray-dried pyrazinoic acid formulations

This study develops and evaluates inhaled POA formulations to improve TB treatment by enhancing pulmonary exposure and efficacy against pncA-mutant Mtb.

Fc mediated pan-sarbecovirus protection after alphavirus vector vaccination

This study shows that non-neutralizing antibodies targeting FcR4 and spike S2 provide cross-protection against sarbecoviruses after alphavirus vector vaccination.

A Multitrait Locus Regulates Sarbecovirus Pathogenesis

The paper identifies a multitrait locus on mouse Chromosome 9 that regulates SARS-CoV, SARS-CoV-2, and bat sarbecovirus disease severity, with candidate genes CCR9 and CXCR6.

SARS-CoV-2 neutralising antibodies in Dogs and Cats in the United Kingdom

This study reports the first large-scale serological survey of SARS-CoV-2 neutralising antibodies in dogs and cats in the UK, finding low prevalence during the second wave of human infections.

Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants

This study assesses the durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants over seven months, finding persistent but reduced binding and functional responses.

Sequence analysis of SARS-CoV-2 in nasopharyngeal samples from patients with COVID-19 illustrates population variation and diverse phenotypes, placing the in vitro growth properties of B.1.1.7 and B.1.351 lineage viruses in context.

The paper analyzes SARS-CoV-2 sequence variation in patient samples and compares the in vitro growth of B.1.1.7 and B.1.351 variants to other isolates, finding no significant difference in growth for B.1.1.7.

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR/Cas9 screening

The paper functionally links gene fusions to cancer cell fitness using drug sensitivity and CRISPR-Cas9 data, identifying rare functional fusions and novel therapeutic targets.

Evidence that recurrent Group A streptococcus tonsillitis is animmunosusceptibility disease involving antibody deficiency and aberrant Tfh cells

The paper investigates recurrent Group A Streptococcus tonsillitis and finds it involves antibody deficiency and aberrant Tfh cells, with genetic factors contributing to susceptibility.

Identifying Migrant Origins Using Genetics, Isotopes, and Habitat Suitability

The paper develops a method combining genetics, isotopes, and habitat suitability to infer migratory origins, showing improved accuracy when integrated.