A. I. Flamholz

This paper predicts microbial dioxygen utilization from genome sequences without gene annotation, achieving >70% accuracy and demonstrating environmental correlations.

The paper maps the sequence-to-function relationship of rubisco by assaying single amino acid mutants in E. coli, identifying conserved positions and mutations that improve CO2 affinity.

The paper introduces a conceptual model explaining how closed microbial ecosystems self-organize to stabilize nutrient cycles and extract energy efficiently.

The paper shows that bacterial secretions, particularly redox-active molecules, can interfere with optical O2 sensors, complicating O2 measurements in bacterial cultures and biofilms.

The paper measures carbon isotope fractionation of an ancestral rubisco in cyanobacteria, showing that evolutionary changes in photosynthesis physiology, not just atmospheric CO2, affect the carbon isotope record.

This paper studies the evolution of bacterial CO2-concentrating mechanisms by engineering E. coli to express ancestral forms of these systems and testing their growth under varying CO2 concentrations.

The paper introduces a database of human impacts on Earth, providing curated quantitative data and analysis of their interconnected effects.

This study identifies a novel photorespiration pathway in chemolithoautotrophic bacteria, revealing the glycerate pathway as the main route and the malate cycle as an oxidative alternative.