Cell BiologybioRxiv
Lung injury epigenetically primes mesenchyme for amplified activation upon re-injury
D. L. Jones, N. Caporarello, J. A. Meridew…·D. J. Tschumperlin
This study shows that lung mesenchyme retains epigenetic memory of prior injury, leading to amplified fibrogenic responses upon re-injury, with Runx1 playing a key role.