Author

N. Caporarello

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pathology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

D. J. Tschumperlin· 3 shared G. Ligresti· 3 shared J. A. Meridew· 3 shared P. A. Link· 3 shared D. L. Jones· 2 shared K. M. Choi· 2 shared Q. Tan· 2 shared T. Ordog· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCell Biology

D. J. Tschumperlin

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Author profile →

4 papers

Recent·Most cited

A redox-shifted fibroblast subpopulation emerges in the fibrotic lung.

P. A. Link, J. A. Meridew, N. Caporarello, A. Y. Gao, V. Peters, G. B. Smith, M. Rojas, D. J. Tschumperlin

The paper identifies a redox-shifted fibroblast subpopulation in fibrotic lungs, showing increased pro-fibrotic activity and reduced collagenolytic activity.

bioRxiv · Sep 23, 2023Pathology

Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell Regeneration

A. A. Raslan, T. X. Pham, J. Lee, J. Hong, J. K. Schmottlach, K. Nicolas, M. D. Taha, A. M. Bujor, N. Caporarello, A. Thiriot, U. H. von Andrian, S. K. Huang, R. F. Nicosia, M. Trojanowska, X. Varelas, G. Ligresti

This study uses single-cell transcriptomics to analyze aging-related changes in lung regeneration and fibrosis in mice, identifying age-associated cellular and molecular alterations.

bioRxiv · Jan 17, 2023Pathology

Lung injury epigenetically primes mesenchyme for amplified activation upon re-injury

D. L. Jones, N. Caporarello, J. A. Meridew, K. M. Choi, A. J. Haak, P. A. Link, Q. Tan, T. Ordog, G. Ligresti, D. J. Tschumperlin

This study shows that lung mesenchyme retains epigenetic memory of prior injury, leading to amplified fibrogenic responses upon re-injury, with Runx1 playing a key role.

bioRxiv · Mar 4, 2022Cell Biology

ZNF416 is a pivotal transcriptional regulator of fibroblast mechano-activation

D. L. Jones, J. A. Meridew, M. T. Ducharme, K. L. Lydon, K. M. Choi, N. Caporarello, Q. Tan, P. A. Link, A. M. Diaz Espinosa, Y. Xiong, J.-H. Lee, Z. Ye, H. Yan, T. Ordog, G. Ligresti, , D. J. Tschumperlin

This study identifies ZNF416 as a key transcriptional regulator that mediates fibroblast responses to matrix stiffness through chromatin accessibility and gene expression changes.

bioRxiv · Jul 23, 2020Cell Biology