Author

P. A. Link

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

D. J. Tschumperlin· 3 shared J. A. Meridew· 3 shared N. Caporarello· 3 shared D. L. Jones· 2 shared G. Ligresti· 2 shared K. M. Choi· 2 shared Q. Tan· 2 shared T. Ordog· 2 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCell Biology

D. J. Tschumperlin

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4 papers

Recent·Most cited

A redox-shifted fibroblast subpopulation emerges in the fibrotic lung.

P. A. Link, J. A. Meridew, N. Caporarello, A. Y. Gao, V. Peters, G. B. Smith, M. Rojas, D. J. Tschumperlin

The paper identifies a redox-shifted fibroblast subpopulation in fibrotic lungs, showing increased pro-fibrotic activity and reduced collagenolytic activity.

bioRxiv · Sep 23, 2023Pathology

Lung injury epigenetically primes mesenchyme for amplified activation upon re-injury

D. L. Jones, N. Caporarello, J. A. Meridew, K. M. Choi, A. J. Haak, P. A. Link, Q. Tan, T. Ordog, G. Ligresti, D. J. Tschumperlin

This study shows that lung mesenchyme retains epigenetic memory of prior injury, leading to amplified fibrogenic responses upon re-injury, with Runx1 playing a key role.

bioRxiv · Mar 4, 2022Cell Biology

ZNF416 is a pivotal transcriptional regulator of fibroblast mechano-activation

D. L. Jones, J. A. Meridew, M. T. Ducharme, K. L. Lydon, K. M. Choi, N. Caporarello, Q. Tan, P. A. Link, A. M. Diaz Espinosa, Y. Xiong, J.-H. Lee, Z. Ye, H. Yan, T. Ordog, G. Ligresti, , D. J. Tschumperlin

This study identifies ZNF416 as a key transcriptional regulator that mediates fibroblast responses to matrix stiffness through chromatin accessibility and gene expression changes.

bioRxiv · Jul 23, 2020Cell Biology

The Influence of Aging and Mechanical Stretch in Alveolar Epithelium ER Stress and Inflammation

M. S. Valentine, J. A. Herbert, P. A. Link, F. J. Kamga Gninzeko, M. B. Schneck, K. Shankar, J. Nkwocha, A. M. Reynolds, R. L. Heise

This study investigates how aging and mechanical stretch increase ER stress and inflammation in alveolar epithelial cells, showing that 4-PBA reduces these effects.

bioRxiv · Jun 30, 2017Bioengineering