A. J. Mitchell

Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY

This study identifies a proton exchange-based isomerization and lactonization mechanism in the plant enzyme COSY, revealing its unique catalytic activity and evolutionary adaptation.

A distinct CD115- erythro-myeloid precursor present at the maternal-embryonic interface and in the bone marrow of adult mice

The paper identifies a CD115- macrophage precursor in adult bone marrow that shares features with embryonic erythro-myeloid progenitors and is present at the maternal-embryonic interface.

Cysteine dependence in Lactobacillus iners constitutes a novel therapeutic target to modify the vaginal microbiota

This study identifies cysteine dependence in Lactobacillus iners as a therapeutic target to shift vaginal microbiota from L. iners-dominant to L. crispatus-dominant states.

Early immune pressure imposed by tissue resident memory T cells sculpts tumour evolution in non-small cell lung cancer

The paper shows that TRM immune pressure in ever-smokers shapes tumour evolution and immune evasion, with implications for immunotherapy.