D. S. Kwon

Prevotella are major contributors of sialidases in the human vaginal microbiome.

This study identifies Prevotella as a major source of sialidases in the vaginal microbiome, showing their prevalence and activity compared to Gardnerella.

Vaginal Lactobacillus fatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment

This study identifies oleic acid as a compound that inhibits L. iners and promotes L. crispatus growth, offering a potential new treatment strategy for bacterial vaginosis.

Longitudinal dynamics of the human vaginal ecosystem across the reproductive cycle

This study tracks changes in the vaginal microbiome and inflammation across the reproductive cycle, finding that childbirth disrupts microbial communities and reduces Lactobacillus dominance, with limited recovery over one year.

Colon resident CD8+ T cells from people with HIV on antiretroviral therapy exhibit mitochondrial dysfunction and impaired responses

The paper examines CD8+ T cells in the colon of HIV patients on ART, finding impaired mitochondrial function and reduced immune responses compared to peripheral blood cells.

Tobacco smoke exposure results in recruitment of inflammatory airspace monocytes and accelerated growth of Mycobacterium tuberculosis

Tobacco smoke exposure recruits inflammatory monocytes to the lungs, which support faster Mycobacterium tuberculosis growth.

Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip

This paper develops a human vagina-on-a-chip model to study vaginal microbiome-host interactions and their effects on health outcomes.

Sub-communities of the vaginal ecosystem in pregnant and non-pregnant women.

The paper identifies non-Lactobacillus-dominated sub-communities in vaginal ecosystems of pregnant and non-pregnant women using mixed membership models, revealing associations with preterm birth and menstrual cycle changes.

Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens

The paper shows that spatially restricted protease activity in lymph node follicles preserves antigen integrity, leading to stronger GC responses when antigens are targeted to follicular dendritic cells.

Cysteine dependence in Lactobacillus iners constitutes a novel therapeutic target to modify the vaginal microbiota

This study identifies cysteine dependence in Lactobacillus iners as a therapeutic target to shift vaginal microbiota from L. iners-dominant to L. crispatus-dominant states.