Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
6 papers
Recent·Most cited
C. Yapp, A. J. Nirmal, F. Y. Zhou…·P. K. Sorger
This paper introduces 3D CyCIF, a method for high-plex 3D profiling of cell states and immune niches in human tumors, revealing detailed spatial interactions and cytokine niches previously unattainable in thin sections.
Z. Maliga, D. Y. Kim, A.-T. N. Bui…·N. R. LeBoeuf
This study compares CyCIF and IHC for immune profiling in ICI-induced dAEs, finding CyCIF provides more detailed single-cell characterization of immune infiltrates.
S. Warchol, R. Krueger, A. J. Nirmal…·H. Pfister
Visinity analyzes spatial cell interactions in multiplexed tissue images to identify biological processes and immune-tumor interactions.
A. J. Nirmal, Z. Maliga, T. Vallius…·P. K. Sorger
The paper uses spatial techniques to study immune evasion and immunoediting in primary melanoma, finding localized immunosuppressive environments and coexistence of invasion and regression.
Z. Maliga, A. J. Nirmal, N. G. Ericson…·P. K. Sorger
Pick-Seq enables deep spatial transcriptomic profiling of fixed human tissue, revealing transcriptional differences in tumor invasion, proliferation, and immuno-editing.
M. Kalocsay, Z. Maliga, A. J. Nirmal…·P. Sorger
The paper uses multiplexed proteomics and imaging to compare inflammatory and thrombotic responses in resolving SARS-CoV-2 infection in rhesus macaques and lethal COVID-19 in humans.