Author

T. Vallius

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:spatial transcriptomics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:batch correction / integration· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

P. K. Sorger· 3 shared A. J. Nirmal· 2 shared S. Santagata· 2 shared A. A. Chen· 1 shared A. Farkkila· 1 shared A. Hurlstone· 1 shared A. Junquera· 1 shared A. Nagaraj· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

P. K. Sorger

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Chemotherapy induces myeloid-driven spatial T-cell exhaustion in ovarian cancer

I.-M. P. Launonen, E. P. Erkan, I. Niemiec, A. Junquera, M. Hincapie-Otero, D. Afenteva, Z. Liang, M. Salko, A. Szabo, F. Perez-Villatoro, M. M. Falco, Y. Li, G. Micoli, A. Nagaraj, U.-M. Haltia, , A. Farkkila

This study shows chemotherapy causes myeloid-driven spatial T-cell exhaustion in ovarian cancer by altering immune cell states and interactions, suggesting new immunotherapy approaches.

bioRxiv · Mar 19, 2024 · PreprintCancer Biology

Quality Control for Single Cell Analysis of High-plex Tissue Profiles using CyLinter

G. J. Baker, E. Novikov, Z. Zhao, T. Vallius, J. A. Davis, J.-R. Lin, J. L. Muhlich, E. A. Mittendorf, S. Santagata, J. L. Guerriero, P. K. Sorger

This paper introduces CyLinter, a quality control tool that removes imaging artefacts from high-plex spatial profiling data, improving single-cell analysis of archival tumor specimens.

bioRxiv · Nov 1, 2023Pathology

Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis

V. Gopalan, C. W. Wong, R. Leshem, L. Owen, T. Vallius, Y. Shi, Y. Jiang, E. Perez-Guijarro, E. Wu, S. Chin, J. Ebersole, C. Smith, A. Sassano, M. Alves Constantino, M. J. Haley, , K. L. Marie

This paper identifies transitory Schwann Cell Precursor and hybrid states in melanoma that correlate with therapy resistance and metastasis, and shows targeting Hdac2 can sensitize tumors to treatment.

bioRxiv · Oct 14, 2022 · PreprintCancer Biology

The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution

A. J. Nirmal, Z. Maliga, T. Vallius, B. Quattrochi, A. A. Chen, C. A. Jacobson, R. J. Pelletier, C. Yapp, R. Arias-Camison, Y.-A. Chen, C. G. Lian, G. F. Murphy, S. Santagata, P. K. Sorger

The paper uses spatial techniques to study immune evasion and immunoediting in primary melanoma, finding localized immunosuppressive environments and coexistence of invasion and regression.

bioRxiv · May 23, 2021Cancer Biology