Author

A. Rustagi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

C. A. Blish· 6 shared A. Beck· 2 shared C. J. Miller· 2 shared D. Fox· 2 shared L. Fritts· 2 shared M. K. Morris· 2 shared S. Stanley· 2 shared T. Carroll· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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6 shared papersImmunology

C. A. Blish

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Administration of vaccine-boosted COVID-19 convalescent plasma to SARS-CoV-2 infected hamsters decreases virus replication in lungs and hastens resolution of the infection despite transiently enhancing disease and lung pathology.

T. Carroll, T. Wong, M. K. Morris, C. Di Germanio, Z.-M. Ma, M. Stone, E. E. Ball, L. Fritts, A. Rustagi, G. Simmons, M. P. Busch, C. J. Miller

This study shows that vaccine-boosted convalescent plasma reduces SARS-CoV-2 replication in hamsters but temporarily worsens disease and lung pathology.

bioRxiv · Aug 22, 2023 · PreprintImmunology

Design of SARS-CoV-2 protease inhibitors with improved affinity and reduced sensitivity to mutations

M. Westberg, Y. Su, X. Zou, P. Huang, A. Rustagi, J. Garhyan, P. B. Patel, D. Fernandez, Y. Wu, L. Ning, A. Beck, M. Karim, C. Hao, P. Saenkham-Huntsinger, V. Tat, , M. Z. Lin

This study designs a SARS-CoV-2 protease inhibitor with improved affinity and reduced mutation sensitivity compared to existing drugs.

bioRxiv · Jul 19, 2023 · PreprintMicrobiology

SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D

M. J. Lee, M. W. Leong, A. Rustagi, A. Beck, L. Zeng, S. Holmes, L. S. Qi, C. A. Blish

This study shows SARS-CoV-2 evades NK cell killing by downregulating NKG2D ligands via Nsp1, reducing NK cell cytotoxicity against infected cells.

bioRxiv · Jun 20, 2022Immunology

SARS-CoV-2 infects human adipose tissue and elicits an inflammatory response consistent with severe COVID-19

G. J. Martinez-Colon, K. Ratnasiri, H. Chen, S. Jiang, E. Zanley, A. Rustagi, R. Verma, H. Chen, J. R. Andrews, K. Mertz, A. Tzankov, D. Azagury, J. Boyd, G. P. Nolan, C. M. Schürch, , T. L. McLaughlin

This study shows SARS-CoV-2 infects human adipose tissue, causing inflammation linked to severe COVID-19 outcomes in obese individuals.

bioRxiv · Oct 24, 2021 · PreprintImmunology

The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters

T. Carroll, D. Fox, N. van Doremalen, E. Ball, M. K. Morris, A. Sotomayor-Gonzalez, V. Servellita, A. Rustagi, C. K. Yinda, L. Fritts, J. R. Port, Z.-M. Ma, M. Holbrook, J. Schulz, C. A. Blish, , C. J. Miller

This study shows that the B.1.427/1.429 (epsilon) SARS-CoV-2 variants cause more severe disease and higher viral loads in the upper respiratory tract in Syrian hamsters compared to the ancestral B.1 (614G) strain.

bioRxiv · Aug 25, 2021Microbiology

An intranasal ASO therapeutic targeting SARS-CoV-2

C. Zhu, J. Y. Lee, J. Z. Woo, L. Xu, X. Nguyenla, L. H. Yamashiro, F. Ji, S. B. Biering, E. V. Dis, F. Gonzalez, D. Fox, A. Rustagi, B. A. Pinsky, C. A. Blish, C. Chiu, , A. M. Näär

This paper develops an intranasal ASO therapy targeting SARS-CoV-2 RNA that effectively prevents viral replication in multiple models and variants.

bioRxiv · May 17, 2021Microbiology

Additional analyses exploring the hypothesized transdifferentiation of plasmablasts to developing neutrophils in severe COVID-19

A. J. Wilk, A. Rustagi, N. Q. Zhao, B. A. Martin, A. J. Rogers, C. A. Blish

The paper responds to criticisms of a previous study on transdifferentiation of plasmablasts to neutrophils in severe COVID-19 using single-cell transcriptomic data.

bioRxiv · Oct 15, 2020 · PreprintImmunology

Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures

A. A. Salahudeen, S. S. Choi, A. Rustagi, J. Zhu, S. M. de la O, R. A. Flynn, M. Margalef-Catala, A. J. M. Santos, J. Ju, A. Batish, V. van Unen, T. Usui, G. X. Y. Zheng, C. E. Edwards, L. E. Wagar, , C. J. Kuo

This paper develops a feeder-free organoid culture system for human distal lung progenitors and demonstrates SARS-CoV-2 infection of club cells in a novel in vitro model.

bioRxiv · Jul 27, 2020 · PreprintCell Biology