B. Wei

Colorectal ALOX15 as a host factor determinant of EPA and DHA effects on colorectal carcinogenesis

This study shows that ALOX15 expression modulates EPA and DHA effects on colorectal carcinogenesis by promoting resolvin generation, which suppresses pro-tumorigenic inflammation.

NLRP3, NLRP6, and NLRP12 are inflammasomes with distinct expression patterns

The paper identifies NLRP3, NLRP6, and NLRP12 as inflammasomes with distinct expression patterns and activation mechanisms in different cell types.

The stability of lower genital tract microbiota correlates with reproductive system function and in vitro fertilization and frozen embryo transfer outcomes in women with polycystic ovarian syndrome

This study investigates the relationship between lower genital tract microbiota and reproductive outcomes in PCOS patients, finding that higher Lactobacillus abundance correlates with better IVF-FET outcomes.

Caspase-1 activates gasdermin A in non-mammals

The paper shows that caspase-1 activates GSDMA in non-mammals like amphibians, reptiles, and birds, revealing an evolutionary shift in caspase-1's target gasdermin.

Cool temperature acclimation in toxigenic Microcystis aeruginosa PCC 7806 and its non-toxigenic mutant

This study compares microcystin production in a toxigenic and non-toxigenic strain of M. aeruginosa under cold temperatures, showing increased microcystin quota and physiological changes in the wildtype.

S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice

This study identifies S100A4 as a potent mucosal adjuvant in mice that enhances antigen-specific immune responses without adverse effects.

High resolution ultrasonic neural modulation observedvia in vivo two-photon calcium imaging

This study develops a dual-modality system to investigate high-frequency ultrasound's effect on neuronal activity in awake mice, achieving 100-micron spatial resolution.

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

Single-cell multi-omic profiling identifies immune dysregulation in severe COVID-19, including neutrophil hyperactivation and anti-inflammatory monocytes.

Clear optically matched panoramic access channel technique (COMPACT) for large-volume deep brain imaging

The paper introduces COMPACT, a technique that significantly increases tissue access volume for deep brain imaging, enabling multiregional calcium imaging of deep brain functions associated with sleep.

Identification of sulfenylated cysteines in Arabidopsis thaliana proteins using a disulfide-linked peptide reporter

This study identifies sulfenylated cysteines in Arabidopsis thaliana using a transgenic Yap1 probe, revealing over 1,000 proteins with sulfenylated residues.

Tracing the origin of a new organ by inferring the genetic basis of rumen evolution

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

Neutralizing PD-L1 and PD-L2 Enhances the Efficacy of Immune Checkpoint Inhibitors in Ovarian Cancer.

The paper develops a high-affinity sPD-1 decoy molecule that neutralizes both PD-L1 and PD-L2, showing superior antitumor activity in ovarian cancer models compared to PD-1/PD-L1 antibodies.

Suppression of membranous LRP5 recycling, WNT/β-catenin signaling, and colorectal tumorigenesis by 15-LOX-1 peroxidation of PI3P_linoleic acid

This study shows that 15-LOX-1 metabolism of LA in PI3P reduces LRP5 membrane levels, inhibits Wnt/β-catenin signaling, and suppresses colorectal tumorigenesis in mice.

The Cdc42 GEF, Gef1, promotes uniform protein distribution along the actomyosin ring to enable concentric furrowing

The paper shows that Gef1 and endocytic events ensure uniform Cdc15 distribution along the actomyosin ring, enabling concentric furrow formation during cytokinesis in fission yeast.

Different subtypes of EGFR exon19 mutation can affect prognosis of patients with non-small cell lung adenocarcinoma

The study examines EGFR exon19 mutation subtypes in non-small cell lung adenocarcinoma and finds that CSS mutations are associated with shorter progression-free survival compared to CD/CSS+SNV mutations.

Increased H. pylori stool shedding and EPIYA-D cagA alleles are associated with gastric cancer in an East Asian hospital

The paper assesses H. pylori stool shedding and cagA genotype in gastric cancer patients and non-cancer controls, finding higher stool shedding and association with the East Asian cagA allele.