A. Kanai

Possible acquisition and molecular evolution of vpu genes inferred from comprehensive sequence analysis of human and simian immunodeficiency viruses

This study analyzes Vpu gene sequences from HIV and SIV to classify them into four types and infer their evolutionary origins and divergence.

Genome-resolved meta-omics unveils rock-hosted lifestyle of enigmatic DPANN archaea

This study investigates the lifestyle of DPANN archaea in rock-hosted environments using genome-resolved meta-omics, revealing a symbiotic lifestyle and ecological interactions with bacteria and minerals.

Diversification of Polynucleotide Kinase Clp1 Family Proteins and Their Possible Origins in Eukaryotic Evolution

The paper identifies the evolutionary origin of Clp1 family proteins by analyzing genome data from 358 eukaryotic species and finds that protist Euglenozoa have multiple Clp1 family genes with unique domain structures.

Robust capability of renal tubule fatty acid uptake from apical and basolateral membranes in physiology and disease

This study investigates fatty acid uptake by renal tubule epithelial cells in mice, showing uptake from both blood and urine, and storage as neutral lipids, with CD36 playing a key role in blood-derived uptake.

Distinct Expansion of Group II Introns Depends on the Type of Intron-encoded Protein and Genomic Signatures in Prokaryotes

The paper systematically analyzes group II introns in prokaryotes, finding differences in their expansion based on intron-encoded protein types and genomic signatures.

HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

This study identifies the HBO1-MLL interaction as critical for leukemogenesis by facilitating the AF4/ENL/P-TEFb complex-mediated gene activation in MLL fusion proteins.

HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

This study shows HOXA9 promotes MYC-driven leukemogenesis by maintaining anti-apoptotic gene expression through multiple pathways.