T. Yokoyama

This study analyzes the genomic diversity and admixture history of captive tigers in the U.S., finding admixture from all six wild tiger subspecies and developing a reference panel for conservation.

This study investigates the lifestyle of DPANN archaea in rock-hosted environments using genome-resolved meta-omics, revealing a symbiotic lifestyle and ecological interactions with bacteria and minerals.

The paper investigates how human insulin resistance to degradation by IDE varies with dose and identifies structural features of the insulin hexamer that influence degradation kinetics without zinc.

This study identifies a cilia-independent role of CEP290 in non-ciliated cells by regulating microtubule elongation and focal adhesion through its interaction with APC.

The paper reports the cryo-EM structure of RNA polymerase engaged with Rho, revealing how Rho interacts with RNAP to mediate transcription termination.

This study investigates fatty acid uptake by renal tubule epithelial cells in mice, showing uptake from both blood and urine, and storage as neutral lipids, with CD36 playing a key role in blood-derived uptake.

This study elucidates the mechanism of intramembrane proteolysis by E. coli RseP through crystal structures and mutational analysis, revealing a gating mechanism for substrate entry.

A marine sponge-derived lectin activates the thrombopoietin receptor by promoting dimerization and exhibits synergy with thrombopoietin, affecting receptor internalization.

This study identifies GGP1 and GGP3 as key enzymes for glutathione degradation in Arabidopsis, showing they contribute significantly to cytosolic GSH turnover alongside GGCTs.

The paper tracks phenotypic and genomic adaptation in Drosophila over ten generations, showing rapid and dynamic responses to environmental change.

This study uses deep learning to classify central serous chorioretinopathy from OCT images, achieving high accuracy with different models and showing DL focuses on choroidal vessel regions.

This study uses GWAS to identify candidate genes in Arabidopsis thaliana associated with root architecture changes in response to Bacillus pumilus TUAT-1 inoculation.

This paper reports the cryo-EM structure of the human LAT1-CD98hc heterodimer, revealing its architecture and interactions, and maps disease mutations to explain congenital disorders.

This study examines how kuruma shrimp adjust free amino acid concentrations and gene expression in response to different salinity levels.

This study shows that sivelestat reduces gefitinib-induced pneumonitis in mice by lowering neutrophil elastase activity and improving survival.