Altered O-glycosylation Level of SARS-CoV-2 Spike Protein by Host O-glycosyltransferase Strengthens Its Trimeric Structure
Z. Xu, X. Ku, J. Tian, H. Zhang, J. Hou, C. Zhang, J. Shi, Y. Li, H. Kaji, S.-c. Tao, A. Kuno, W. Yan, L.-T. Da, Y. Zhang
The paper identifies O-glycosylation sites on SARS-CoV-2 spike protein and shows that host O-glycosyltransferase ppGalNAc-T6 enhances its trimeric structure stability through increased glycosylation.
bioRxiv · Apr 6, 2021 · PreprintBiochemistry