Author

L.-t. Da

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Organism:human· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

W. Yan· 2 shared Y. Zhang· 2 shared A. Kuno· 1 shared C. E· 1 shared C. Long· 1 shared C. Zhang· 1 shared H. Kaji· 1 shared H. Zhang· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

W. Yan

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Discovery and Engineering of the L-Threonine Aldolase from Neptunomonas Marine for Efficient Synthesis of β-Hydroxy-α-Amino Acids via C-C Formation

Y. He, S. Li, J. Wang, X. Yang, J. Zhu, Q. Zhang, L. Cui, Z. Tan, Y. Zhang, W. Yan, L. Tang, L.-t. Da, Y. Feng

This paper discovers and engineers an L-threonine aldolase from Neptunomonas marine to efficiently synthesize β-hydroxy-α-amino acids with high diastereoselectivity.

bioRxiv · Apr 9, 2023 · PreprintBiochemistry

Altered O-glycosylation Level of SARS-CoV-2 Spike Protein by Host O-glycosyltransferase Strengthens Its Trimeric Structure

Z. Xu, X. Ku, J. Tian, H. Zhang, J. Hou, C. Zhang, J. Shi, Y. Li, H. Kaji, S.-c. Tao, A. Kuno, W. Yan, L.-T. Da, Y. Zhang

The paper identifies O-glycosylation sites on SARS-CoV-2 spike protein and shows that host O-glycosyltransferase ppGalNAc-T6 enhances its trimeric structure stability through increased glycosylation.

bioRxiv · Apr 6, 2021 · PreprintBiochemistry

Allosteric regulation in CRISPR/Cas1-Cas2 protospacer acquisition mediated by DNA in association with Cas2

C. Long, L. Dai, C. E, L.-T. Da, J. Yu

This study shows that PAMc recognition and cleavage in one Cas1-Cas2 site allosterically regulate non-PAMc association in the other site, mediated by Cas2 and DNA.

bioRxiv · Oct 30, 2020 · PreprintBiophysics

Designed peptides as potential fusion inhibitors against SARA-CoV-2 coronavirus infection

K. Chen, S. Bai, X. Zou, J. Hao, L.-t. Da, Z.-G. Han

The paper designs peptides based on SARS-CoV-2 spike protein HR1/HR2 domains to inhibit viral fusion and entry into host cells, showing they can form complexes with HR1 peptides.

bioRxiv · Jun 9, 2020 · PreprintMicrobiology