W. Yan

Epigenetic upregulation of carotid body angiotensin signaling increases blood pressure

This study shows perinatal nicotine exposure increases DNA methylation in the angiotensin II type 1 receptor gene in carotid bodies, enhancing angiotensin signaling and leading to hypertension.

Hackflex library preparation enables low-cost metagenomic profiling

This study evaluates Hackflex library preparation for metagenomic sequencing, showing it recovers all members of a mock community and distinguishes microbiota between individual mice.

The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity

The paper introduces the Natural Products Discovery Center, releasing 8490 sequenced Actinobacteria strains and highlighting their taxonomic and biosynthetic diversity.

SEPALLATA-driven MADS transcription factor tetramerization is required for inner whorl floral organ development

The paper shows that SEPALLATA-driven MADS tetramerization is essential for inner whorl floral organ identity, beyond its role in meristem determinacy.

Transcriptomic Analysis Of The Ocular Posterior Segment Completes A Cell Atlas Of The Human Eye

This paper completes a cell atlas of the human eye by analyzing the posterior segment using snRNA-seq, identifying 37 cell types and mapping glaucoma-associated gene expression.

ZBP1-mediated macrophage necroptosis inhibits ASFV replication

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

Discovery and Engineering of the L-Threonine Aldolase from Neptunomonas Marine for Efficient Synthesis of β-Hydroxy-α-Amino Acids via C-C Formation

This paper discovers and engineers an L-threonine aldolase from Neptunomonas marine to efficiently synthesize β-hydroxy-α-amino acids with high diastereoselectivity.

Metformin regulates bone marrow stromal cells to accelerate bone healing in diabetic mice

This study shows metformin improves bone healing in diabetic mice by enhancing BMSC differentiation and chondrogenesis.

Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer

This study shows Notch signaling in tumor-associated macrophages promotes immunosuppression in pancreatic cancer, and blocking it enhances immune therapy effectiveness.

Maximum Classifier Discrepancy Generative Adversarial Network for Jointly Harmonizing Scanner Effects and Improving Reproducibility of Downstream Tasks

This paper introduces MCD-GAN, a method that harmonizes scanner effects in MRI data while preserving biological information, improving cross-scanner classification performance.

Discovery of aphid-transmitted Rice tiller inhibition virus from native plants through metagenomic sequencing

The paper discovers a new aphid-transmitted rice virus, RTIV, from wild rice plants and shows it causes low-tillering disease in rice cultivars.

Innate-adaptive IFN cross-talk reprograms myeloid and T cells for antitumor immunity with a second-generation recombinant MVA

This paper describes a second-generation recombinant MVA vaccine that enhances antitumor immunity by reprogramming myeloid and T cells through innate-adaptive IFN cross-talk.

Isoform-specific Disruption of the TP73 Gene Reveals a Critical Role for TAp73gamma in Tumorigenesis via Leptin

This study shows that the p73{gamma}-Leptin pathway promotes tumorigenesis and alters lipid metabolism by demonstrating that E11 deletion increases p73{gamma} and Leptin, leading to oncogenic effects in mice and human cancers.

Temporal single cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury

The paper creates a temporal single-cell atlas of non-neuronal retinal cells in mice after CNS injury, revealing dynamic multicellular responses and an interferon program.

Arginase 1 is a key driver of immune suppression in pancreatic cancer

This study shows that Arginase 1 suppresses immune responses in pancreatic cancer by inhibiting T cell activation, and targeting it enhances immunotherapy effectiveness.

Bioprinting microporous functional living materials from protein-based core-shell microgels

This paper introduces a core-shell microgel bioprinting method to create functional living materials with controlled microporosity and enhanced bioprocessing capabilities.

Low-cost genomics enable high-throughput isolate screening and strain-level microbiome profiling

This study develops a low-cost method for high-throughput bacterial isolation and genome sequencing, revealing recombination hotspots and plasmid transmission in chimpanzee gut microbiota.

Boosting transformation in wheat by BBM-WUS

This paper introduces a heat-shock protocol for wheat transformation that significantly improves efficiency using BBM-WUS, reducing the time to obtain transgenic plants to 60 days.

Euchromatin activity enhances segregation and compaction of heterochromatin in the cell nucleus

This study models nuclear chromatin organization using active Zimm chains to show how euchromatin activity drives heterochromatin segregation and compaction through hydrodynamic interactions and crosslinking.

Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types

The paper creates a cell atlas of the human eye's anterior segment using snRNA-seq, identifying over 60 cell types and their gene expression patterns across tissues, with implications for understanding ocular diseases.

Intratumoral delivery of engineered recombinant modified vaccinia virus Ankara express-ing Flt3L and OX40L generates potent antitumor immunity through activating the cGAS/STING pathway and depleting tumor-infiltrating regulatory T cells

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming.

This study shows that extrinsic KRAS signaling reprograms pancreatic fibroblasts to create an inflammatory microenvironment that supports tumor growth.

Wall-associated Receptor Kinase and The Expression Profiles in Wheat Responding to Fungal Stress

This study classifies wheat WAKs and WAKLs, identifies structural features, and shows that TaWAK75 and TaWAK76b are involved in resistance to Bgt.

A 3D gene expression atlas of the floral meristem based on spatial reconstruction of single nucleus RNA sequencing data

The paper reconstructs 3D gene expression patterns in a floral meristem using single-nuclei RNA-seq and spatial reconstruction to study cell identity and organ patterning.

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

The paper identifies a novel binding site on α-tubulin and shows that cevipabulin binding to this site induces tubulin degradation.

A new role of low barrier hydrogen bond in mediating protein stability by small molecules

This study identifies a novel role of low barrier hydrogen bonds in promoting selective tubulin degradation through small molecule interactions.

Bacteroidales species are a reservoir of phase-variable antibiotic resistance genes in the human gut microbiome

The paper identifies phase-variable antibiotic resistance genes in the human gut microbiome, showing they are prevalent in Bacteroidales species and originate from integrative conjugative elements.

Altered O-glycosylation Level of SARS-CoV-2 Spike Protein by Host O-glycosyltransferase Strengthens Its Trimeric Structure

The paper identifies O-glycosylation sites on SARS-CoV-2 spike protein and shows that host O-glycosyltransferase ppGalNAc-T6 enhances its trimeric structure stability through increased glycosylation.

Destruction of DNA-binding proteins by programmable O'PROTAC: Oligonucleotide-based PROTAC

This paper develops OPROTACs, programmable molecules that degrade DNA-binding proteins like ERG and LEF1, showing potential for targeting undruggable transcription factors in cancer.

Immunoengineered Nanobead System for the Isolation and Detection of Circulating Tumor Cells

This paper develops an immuno-fluorescent magnetic nanobead system for capturing, isolating, and detecting circulating tumor cells with high efficiency and viability.